Synthesis and Spectral Characterization of 4,7-Dichloro-6-nitroquinazoline
Round 1
Reviewer 1 Report
This is an interesting Note, which reports a new and simple synthesis of an important heterocyclic derivative (4,7-dichloro-6-nitroquinazoline). The manuscript is well written. The authors have made a comparison between their spectroscopic data and those present in the literature and found some important differences, suggesting that the previous characterization data were actually referred to the product deriving from hydrolysis of 4,7-dichloro-6-nitroquinazoline. Considering this, I believe that it is essential, before publication of the manuscript, that the authors furnish more solid characterization data for the product they synthesized: in particular, HRMS spectra should be provided and, most importantly, XRD data should be given to definitely confirm the molecular structure.
Author Response
Thank you very much for your comments.
We totally agree that HRMS and XRD data are essential for the publication of this paper as a Short Note/Structure Determination paper type. However, we are submitting it as a Communication thanks to a kind recommendation we had from one of the Academic Editors of Molbank, and we think it might fit this category better with the current compound characterization. As reported in the manuscript, the target compound is highly reactive and readily decomposes even at normal storage conditions. This is also evidenced by the fact that it reacts with methanol to form a methoxy-intermediate in a normal MS run. We thus reckon the same phenomenon can occur during a HRMS run. Considering these facts, if it is a prerequisite for a Communication paper to have those listed data, we will work on the update. Please kindly confirm. We really appreciate your considerate comments.Reviewer 2 Report
The authors investigated characteristics of 4,7-dichloro-6-nitroquinazoline. 4,7-Dichloro-6-nitroquinazoline is an important intermediate to synthesize Afatinib. Therefore, the description of characteristics of 4,7-dichloro-6-nitroquinazoline meets the aim for molbank. I agree publication for molbank after following considerations:
- The authors should describe the synthesis methods of compounds II and III with associating the corresponding literatures in the text.
- In experimental section, the authors should associate the synthesis methods of compounds II, III, and IV with the corresponding literatures.
- Ref.[36] is missing in the text. Please correct it.
- On line 82, N-NMR should be changed to C-NMR.
Author Response
Thank you so much for your considerate comments. Please kindly see below our updates.
- The authors should describe the synthesis methods of compounds II and III with associating the corresponding literatures in the text.
The synthesis methods for compounds II and III have been updated with appropriate literature in the text. Please see the updated manuscript.
- In experimental section, the authors should associate the synthesis methods of compounds II, III, and IV with the corresponding literatures.
The synthesis methods for compounds II, III, and IV in the Experimental section have been updated with appropriate literature. Please see the updated manuscript.
- Ref.[36] is missing in the text. Please correct it.
Ref. [36] has been updated. Please see the updated manuscript.
- On line 82, N-NMR should be changed to C-NMR.
The typo has been corrected in the updated manuscript.
Reviewer 3 Report
The paper describes the synthesis of 4,7-dichloro-6-nitroquinazoline in 3 steps, which had not been characterized earlier. Also, an analog was synthesized. The manuscript should be accepted and published
Author Response
Thank you so much for your considerate comments
Round 2
Reviewer 1 Report
I understand the authors' reply to my concerns. Well, if the Academic Editor believes that the Comunication can be published anyway, even without XR and HRMS data, it is fine for me. However, I really hope that in the near future the authors will publish definitive characterization data.
