4-(Benzo[d]thiazol-2-yl)-1-(2-nitrophenyl)-1H-1,2,3-triazol-5-amine

Round 1

Reviewer 1 Report

This manuscript describes the synthesis of 4-(benzo[d]thiazol-2-yl)-1-(2-nitrophenyl)-1H-1,2,3-triazol-5-amine 3 via a dipolar cycloaddition reaction between azido substrate 1 and active methylene compound 2.      

The obtained triazole 3 was well characterized by H¹-NMR, C¹³-NMR, and elemental analysis.

 

However, there is a serious flaw in this manuscript. The synthesis of the regioisomer of 3 using essentially the same dipolar cycloaddition has already been reported by the authors, but they do not cite the literature (Chemistry of Heterocyclic Compounds, 2009, 45, 483.). Therefore, this manuscript should be published as a Short Note, not as a Communications.

 

Furthermore, the amount of base tested (Table 1, Entry 2) is not sufficient to indicate optimal conditions for the reaction; different amounts of Et₃N should be used to indicate optimal reaction conditions.

 

I recommend that the following points be corrected before publication in Molbank.

1) Appropriately cite reference to similar dipolar cycloaddition reactions already reported by the authors. 

2) Clarify the optimal amount of Et₃N.

3) "[12]" should be corrected to "[11]". The content of reference [12] is different. (p1, line 7 from bottom)

4) Put a space between all Celsius degrees.

5) Correct "amines such as" to "amines such as". (p2, line 14 from the bottom)

6) Delete the duplicate 1994. (p3, ref 2)

7) Delete duplicate 1990. (p4, ref 9)

Author Response

Please see the attachment

Author Response File: Author Response.pdf

Reviewer 2 Report

Rephrase "mutually placed".

Rephrase "condensed systems".

Rephrase "reaction embarrassments"

Rephrase "our reagents"

Rephrase " TLC identifying"

Rephrase "extended singlet"

Rephrase " characteristic carbon in position"

 

 

Author Response

Dear Reviewer,

Thanks for your analysis of the results presented in our manuscript.

Please, find below our answers.

Rephrase "mutually placed".

Corrected

Rephrase "condensed systems".

Corrected

Rephrase "reaction embarrassments"

Corrected

Rephrase "our reagents"

Corrected

Rephrase " TLC identifying"

Corrected

Rephrase "extended singlet"

Corrected

Rephrase " characteristic carbon in position"

Corrected

Round 2

Reviewer 1 Report

Publish as is