4-(4-(((1H-Benzo[d][1,2,3]triazol-1-yl)oxy)methyl)-1H-1,2,3-triazol-1-yl)-7-chloroquinoline
, Jiang Ai 1, Yuhan Xie 1, Alessandra Gianoncelli 2, Giovanni Ribaudo 2,* and Paolo Coghi 1,*Round 1
Reviewer 1 Report
This work reported the synthesis of a unique triazole hybrid derivative which is a promising seed molecule for treatment of Alzheimer's disease, although still further structural modification is necessary according to their docking studies.This paper described on the synthetic route and careful structural characterization of the target triazole molecule.
Because of importance of the structure of the target molecule and also computational discussion of the bioactivity, I think this work can be published in Molbank after minor revisions.
1) The synthetic route looks relatively simple. Thus, the authors should explain the benefit of this synthetic route by comparison with the others. For example, as the authors commented, the structure should be further optimized in future. From that point of view, is there any advantage to this synthetic route? e.g. generality of the substrate scope in the azidation or availability of starting materials.
2) In some of the 13C NMR signals, no decimal point was described.
Author Response
Comments reviewer:
This work reported the synthesis of a unique triazole hybrid derivative which is a promising seed molecule for treatment of Alzheimer's disease, although still further structural modification is necessary according to their docking studies.
This paper described on the synthetic route and careful structural characterization of the target triazole molecule.
Because of importance of the structure of the target molecule and also computational discussion of the bioactivity, I think this work can be published in Molbank after minor revisions.
1) The synthetic route looks relatively simple. Thus, the authors should explain the benefit of this synthetic route by comparison with the others. For example, as the authors commented, the structure should be further optimized in future. From that point of view, is there any advantage to this synthetic route? e.g. generality of the substrate scope in the azidation or availability of starting materials.
2) In some of the 13C NMR signals, no decimal point was described.
Reply:
We would like to thanks reviewer for comments to improve quality of paper.
Relatively to 1 point we added some sentence in paragraph 2.
Procedure of scheme 1 (formation of azide and alkyne derivative and following click chemistry reaction) was previously adopted in our paper reference 24 and in second paper published in MolBank (Yun, X.; Xie, Y.; Ng, J.P.L.; Law, B.Y.K.; Wong, V.K.W.; Coghi, P. 2-Bromo-3-((1-(7-chloroquinolin-4-yl)-1H-1,2,3-triazol-4-yl)-methoxy)-benzaldehyde. Molbank 2022, 2022, M1351. https://doi.org/10.3390/M1351). Because fast procedure, high yields and easy separation of products we continued to use same approach for synthesis of compound 5.
Relatively to point 13C NMR signal of experimental part and table S1 of supp information, we added decimals as indicated in yellow.
This manuscript is a resubmission of an earlier submission. The following is a list of the peer review reports and author responses from that submission.
