(R)-(+)-3,5-Dinitro-N-(1-phenylethyl)benzothioamide

Round 1

Reviewer 1 Report

In the presented manuscript Donahue and Crull focused on the fully characterization of (R)-(+)-3,5-Dinitro-N-(1-phenylethyl)benzothioamide especially structure determination by several 1D or 2D-NMR methods. I checked the NMR assignments of the Kagan-amide's thio-derivative and seemed to be correct.  

My comments:

1./ N-[(1R)-1-Phenylethyl]benzenecarbothioamide is a well-known compound, please mention it briefly in the Introduction.

2./ In ¹H-, or ¹³C-NMR spectra ethyl-acetate can be detected and you gave the melting point of 1 79-81°C. So 1 was probably not pure. How can MP be determined so precisely?

3./ Which standard materials were used in the NMR measurements? Please write in the “3.3 Instrumentation and Analysis”.

The manuscript can be published after a minor revision in the „Organic Synthesis” section of Molbank.

Author Response

We thank the editor and the reviewer for their service in reviewing our manuscript. Our responses to the Review Report are listed here:

1. One sentence and three references have been added to the second paragraph on this compound.
2. The thioamide was has been made on many different occasions. The melting point has been measured for each batch. It is consistently in the 79-81°C range.
3. The solvent CDCl₃ has been specified. 
4. While not listed by the reviewer, the 1535 cm^–1 stretch in the IR was originally assigned to the C=S stretch. This was a mistake and has been corrected. It is an NO₂ related stretch.