Methyl-4-hydroxy-2-(2-hydroxypropan-2-yl)-6-methyl-2,3-dihydrobenzofuran-5-carboxylate
Round 1
Reviewer 1 Report
Jaspars et al. report on the characterisation of radstrictin K, isolated from a fungus obtained from a soil sample from the Atacama Desert.
The elucidation of the structure is convincing, and the spectroscopic data are in good agreement with what was expected and close to those obtained for radstrictin B previously reported.
I have difficulty with the paragraph describing the optical rotation and the comparison with radstrictin B. The authors measured the optical rotation (the solvent and concentration are missing!) and obtained +24.6°.
The only thing we can say is that the mixture they have is dextrorotatory, so we can't conclude whether the compound is enantiopure or whether the sample is enriched in one of the two enantiomers.
I think an HPLC analysis equipped with a chiral column, allowing separation of the two enantiomers, is necessary. Any comparison with what has been done for radstrictin B is pointless. Optical rotation values, even for compounds in the same family, should not be compared.
I believe that with this additionnal HPLC chiral analysis, and proper conclusion, the paper can be accepted in molbank.
Author Response
Please see attached.
Author Response File: 
Author Response.pdf
Round 2
Reviewer 1 Report
I believe the paper can now be accepted in molbank after minor revision.
Addition of HPLC conditions, in particular retention time of the compound of interest would be a plus together with HPLC trace in the supporting information.
Author Response
reviewer comments:
I believe the paper can now be accepted in molbank after minor revision.
Addition of HPLC conditions, in particular retention time of the compound of interest would be a plus together with HPLC trace in the supporting information
authors' reply:
Dear reviewer,
Thank you for your comments,
We have updated everything as per your comments in the relevant sections of the main paper and the supplementary information.
