4-(4-Ethoxyphenyl)-5-(4-methoxyphenyl)-2,4-dihydro-3H-1,2,4-triazol-3-one
, Calin Deleanu 2,3, Vasile-Nicolae Bercean 1 and Francisc Péter 1Round 1
Reviewer 1 Report
Manuscript presented by Ion Burcă et al. shows a short note study about a synthesis of 4-(4-ethoxyphenyl)-5-(4-methoxyphenyl)-2,4-dihydro-3H-1,2,4- 2 triazol-3-one. The topic is very important due to potential biological application of this class of organic compounds. Thanks to the Authors for conducting this intriguing study.
An already well written and prepared manuscript. Easy to read and follow. I recommend the article to publish in Molbank but first the paper should be corrected. My decision – reconsider after minor revision. Comments to be considered, in order to further improve the manuscript quality:
(1) The only major comment is that the Authors should add a discussion on the spectral analysis of the obtained compounds 2 and 3.
(2) Is compound 2 also a new connection? Please add information. This is unclear. If it is not a new connection, please provide appropriate reference to synthesis method and compare a melting point with a literature.
(3) In main text please put all numbers of compounds (especially see page 2).
(4) Please add full information (with details) about the reaction method monitoring (e.g. for TLC please add information about eluent and its ration).
(5) Into the supporting material the Authors should also add MS spectra for compound 2.
(6) Please check if all tables, figures, etc. are cited in the main text.
(7) The Authors have to add a conclusion part.
(8) Superscripts and subscripts as well as commas and dots should be checked and correct Avoid extra or lack of spaces and enters. Remove unnecessary capital letters in the text. Correct in whole manuscript.
(9) The English should be improved. Please use British English in the manuscript.
Minor editing of English language required.
Author Response
1) The only major comment is that the Authors should add a discussion on the spectral analysis of the obtained compounds 2 and 3.
Explanation regarding spectral analysis of the compounds (2) and (3) was added to the manuscript.
2) Is compound 2 also a new connection? Please add information. This is unclear. If it is not a new connection, please provide appropriate reference to synthesis method and compare a melting point with a literature.
The compound (2) was not published in a scientific paper, therefore no data regarding physical properties (e.g., melting point) and spectroscopic analysis (NMR, IR spectra) is available. The compound (2) can be found only on chemicals vendors sites and can be purchased from there. According to Reaxys, the compound (2) has a CAS number assigned (CAS no. 861123-07-1). The links below contain very little information on compound (2). Given the above, no synthesis methods are available, and we have no literature data to compare our experimental data with. The compound (2) was fully characterized by 1D and 2D NMR spectroscopy.
Links: https://pubchem.ncbi.nlm.nih.gov/substance/131988444
https://pubchem.ncbi.nlm.nih.gov/compound/3892399
3) In main text please put all numbers of compounds (especially see page 2).
All compounds numbers have been put in the manuscript.
4) Please add full information (with details) about the reaction method monitoring (e.g. for TLC please add information about eluent and its ration).
Information regarding the reaction monitoring method (TLC) and eluent was added to the manuscript.
5) Into the supporting material the Authors should also add MS spectra for compound 2.
The compound (2) is an intermediary in our synthesis, thus we considered that HRMS analysis is not necessary. Moreover, the HRMS analysis was performed outside our university, and the lead time for a new analysis would exceed 1 month.
6) Please check if all tables, figures, etc. are cited in the main text.
All schemes and tables were cited in the manuscript.
7) The Authors have to add a conclusion part.
Conclusion chapter was added to the manuscript.
8) Superscripts and subscripts as well as commas and dots should be checked and correct Avoid extra or lack of spaces and enters. Remove unnecessary capital letters in the text. Correct in whole manuscript.
The manuscript was corrected accordingly.
9) The English should be improved. Please use British English in the manuscript.
Some sentences were rephrased accordingly.
