1,4-Bis(2-((1R,5S)-6,6-dimethylbicyclo[3.1.1]hept-2-en-2-yl)ethyl)piperazine

Round 1

Reviewer 1 Report

N. S. Li-Zhulanov and his group represented the structure of the title compound, which include the synthetic method.

 In the introduction, they explained the aim of synthesizing the title compound in detail, based on their previous research results. This emphasized the importance of the title compound. Moreover, the synthetic procedure is fine, and the structural analysis and the spectrum data are also well organized to show the product.

Overall, I think the manuscript would be acceptable and is enough for publication on Molbank. Short comments are below.

1.        In the ¹H NMR spectrum data, the number of hydrogen atoms is different from that of the compound in lines 99-101 on page 4.

2.        ¹H-NMR and/or ¹³C-NMR should be deleted hyphens in lines 99 and 102 on page 4.

Author Response

We greatly appreciate the comments by the reviewer.

1)    In the 1H NMR spectrum data, the number of hydrogen atoms is different from that of the compound in lines 99-101 on page 4.

Response: We carefully checked the data and corrected the number of hydrogen atoms.

2)    1H-NMR and/or 13C-NMR should be deleted hyphens in lines 99 and 102 on page 4.

Response: Corrected. There is the updated spectrum data:

¹H NMR (CDCl₃, 600 MHz): δ 5.20 (br.s, 2H, H-2), 2.64–2.28 (m, 8H, piperazine), 2.37–2.29 (m, 6H, H-7’, H-11), 2.25–2.10 (m, 8H, H-3, H-10), 2.02–2.06 (m, 2H, H-4), 2.00 (t, J=5.6 Hz, 2H, H-6), 1.24 (s, 6H, CH₃-8), 1.11 (d, J=8.5 Hz, 2H, H-7), 0.79 (s, 6H CH₃-9). ¹³C NMR (CDCl₃, 150 MHz): δ 146.3 (C-1), 116.9 (C-2), 56.7 (C-11), 53.1 (piperazine), 45.9 (C-6), 40.7 (C-4), 37.9 (C-5), 34.3 (C-10), 31.6 (C-7), 31.2 (C-3), 26.2 (C-8), 21.1 (C-9).

Reviewer 2 Report

The manuscript describes the synthesis of the piperazine derivative, 2, which might have pharmaceutical interest. The results are clearly presented and the experimental part rigorously performed and commented. I recommend its publication in the present form.

Author Response

We are deeply grateful for the high appreciation of our work.