Optical-Spectrometry-Based Method for Immunosuppressant Medicine Level Detection in Aqueous Solutions

Marzejon, Marcin; Kosowska, Monika; Majchrowicz, Daria; Bułło-Piontecka, Barbara; Wąsowicz, Michał; Jędrzejewska-Szczerska, Małgorzata

doi:10.3390/s18072001

Open AccessArticle

Optical-Spectrometry-Based Method for Immunosuppressant Medicine Level Detection in Aqueous Solutions

by

Marcin Marzejon

¹

,

Monika Kosowska

¹

,

Daria Majchrowicz

^1,*

,

Barbara Bułło-Piontecka

²

,

Michał Wąsowicz

^3,* and

Małgorzata Jędrzejewska-Szczerska

^1,*

¹

Department of Metrology and Optoelectronics, Faculty of Electronics, Telecommunications and Informatics, Gdańsk University of Technology, 11/12 Narutowicza Street, 80-233 Gdansk, Poland

²

Department of Nephrology, Transplantology and Internal Diseases, Faculty of Medicine, Medical University of Gdańsk, 3a Marii Skłodowskiej-Curie Street, 80-210 Gdansk, Poland

³

Department of Morphological Sciences, Faculty of Veterinary Medicine, Warsaw University of Life Sciences, 159 Nowoursynowska Street, 02-776 Warszawa, Poland

^*

Authors to whom correspondence should be addressed.

Sensors 2018, 18(7), 2001; https://doi.org/10.3390/s18072001

Submission received: 15 May 2018 / Revised: 19 June 2018 / Accepted: 20 June 2018 / Published: 22 June 2018

(This article belongs to the Special Issue Spectroscopy Based Sensors)

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Abstract

In this paper, an investigation into detecting immunosuppressive medicine in aqueous solutions using a spectrometry-based technique is described. Using optical transmissive spectrometry, absorbance measurements in the spectra range from 250 nm to 1000 nm were carried out for different cyclosporine A (CsA) concentrations in aqueous solutions. The experiment was conducted for samples both with and without interferent substances—glucose and sodium chloride. Using a dedicated algorithm, the measured data was analyzed and a high correlation coefficient R² = 0.8647 was achieved. The experiment showed that the described technique allowed for the detection of various CsA concentration levels in a selective, label-free and simple way. This method could be used in medicine, veterinary medicine and laboratory diagnostics.

Keywords: optical spectrophotometry; label-free detection; cyclosporine

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MDPI and ACS Style

Marzejon, M.; Kosowska, M.; Majchrowicz, D.; Bułło-Piontecka, B.; Wąsowicz, M.; Jędrzejewska-Szczerska, M. Optical-Spectrometry-Based Method for Immunosuppressant Medicine Level Detection in Aqueous Solutions. Sensors 2018, 18, 2001. https://doi.org/10.3390/s18072001

AMA Style

Marzejon M, Kosowska M, Majchrowicz D, Bułło-Piontecka B, Wąsowicz M, Jędrzejewska-Szczerska M. Optical-Spectrometry-Based Method for Immunosuppressant Medicine Level Detection in Aqueous Solutions. Sensors. 2018; 18(7):2001. https://doi.org/10.3390/s18072001

Chicago/Turabian Style

Marzejon, Marcin, Monika Kosowska, Daria Majchrowicz, Barbara Bułło-Piontecka, Michał Wąsowicz, and Małgorzata Jędrzejewska-Szczerska. 2018. "Optical-Spectrometry-Based Method for Immunosuppressant Medicine Level Detection in Aqueous Solutions" Sensors 18, no. 7: 2001. https://doi.org/10.3390/s18072001

APA Style

Marzejon, M., Kosowska, M., Majchrowicz, D., Bułło-Piontecka, B., Wąsowicz, M., & Jędrzejewska-Szczerska, M. (2018). Optical-Spectrometry-Based Method for Immunosuppressant Medicine Level Detection in Aqueous Solutions. Sensors, 18(7), 2001. https://doi.org/10.3390/s18072001

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Optical-Spectrometry-Based Method for Immunosuppressant Medicine Level Detection in Aqueous Solutions

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