Neural Predictors of the Antidepressant Placebo Response
Abstract
:1. Introduction
2. Imaging Data Captured in Clinical Trials Primarily Focused on Antidepressant Efficacy or Predicting Antidepressant Response
3. Imaging Experiments Specifically Interrogating Mechanism of Antidepressant Placebo Response
4. Discussion
4.1. Endogenous Opioids and the Antidepressant Placebo Response
4.2. The Reward Network and Antidepressant Placebo Response
4.3. Rostral Anterior Cingulate Cortex and Antidepressant Placebo Response
4.4. Consistent Overlap in Neural Substrates of Antidepressant Placebo and Medication Response
4.5. Salience/Reward Network Functional Connectivity and Other Tools for Future Brain-Based Prospective Identification of Likely Placebo Responders
Author Contributions
Funding
Conflicts of Interest
References
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Reference | N | Method | Brain Regions Associated with Antidepressant Placebo Response |
---|---|---|---|
[15] | 17 | FDG PET after 1 and 6 wks PBO or ADT | rACC, pACC, NAc, OFC, dlPFC, PMC, IPC, Hyp, Tha, SSA, pIns, pHipp; also predict ADT response. |
[16,17] | 51 | EEG at baseline, after 1 week single-blind PBO lead-in, and 2, 4, 6, and 8 wks ADT | Frontocentral cortex |
[18] | 72 | EEG at baseline | None |
[19] | 144 | EEG at baseline, after 1 week PBO | rACC; |
[20] | 248 | EEG at baseline, after 1 week PBO or ADT | rACC; also predicts ADT response |
[21] | 238 | EEG at baseline, after 1 week PBO or ADT, functional connectivity analysis. | rACC, rAI; also predicts ADT response |
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Rette, D.; McDonald, E.; Iosifescu, D.V.; Collins, K.A. Neural Predictors of the Antidepressant Placebo Response. Pharmaceuticals 2019, 12, 158. https://doi.org/10.3390/ph12040158
Rette D, McDonald E, Iosifescu DV, Collins KA. Neural Predictors of the Antidepressant Placebo Response. Pharmaceuticals. 2019; 12(4):158. https://doi.org/10.3390/ph12040158
Chicago/Turabian StyleRette, Danielle, Erin McDonald, Dan V. Iosifescu, and Katherine A. Collins. 2019. "Neural Predictors of the Antidepressant Placebo Response" Pharmaceuticals 12, no. 4: 158. https://doi.org/10.3390/ph12040158