New Insights into the Stereochemical Requirements of the Bombesin BB1 Receptor Antagonists Binding
Abstract
:1. Introduction
2. Results and Discussion
Proof of Concept
3. Materials and Methods
3.1. Molecular Modeling
3.2. Binding Assays
4. Conclusions
Author Contributions
Funding
Acknowledgments
Conflicts of Interest
Appendix A
References
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Compound# | Chemical Structure | BB1R(Neuromendin B Receptor) Radioligand Displacement (%) | BB2R(Gastrin-Releasing Peptide Receptor) Radioligand Displacement (%) |
---|---|---|---|
1 | | 19.7 | 0.0 |
2 | | 24.3 | 0.0 |
3 | | 28.1 | 0.0 |
4 | | 30.5 | 0.0 |
5 | | 38.0 | 10.5 |
6 | | 16.1 | 0.0 |
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Rasaeifar, B.; Gomez-Gutierrez, P.; Perez, J.J. New Insights into the Stereochemical Requirements of the Bombesin BB1 Receptor Antagonists Binding. Pharmaceuticals 2020, 13, 197. https://doi.org/10.3390/ph13080197
Rasaeifar B, Gomez-Gutierrez P, Perez JJ. New Insights into the Stereochemical Requirements of the Bombesin BB1 Receptor Antagonists Binding. Pharmaceuticals. 2020; 13(8):197. https://doi.org/10.3390/ph13080197
Chicago/Turabian StyleRasaeifar, Bahareh, Patricia Gomez-Gutierrez, and Juan J. Perez. 2020. "New Insights into the Stereochemical Requirements of the Bombesin BB1 Receptor Antagonists Binding" Pharmaceuticals 13, no. 8: 197. https://doi.org/10.3390/ph13080197