Advances on Greener Asymmetric Synthesis of Antiviral Drugs via Organocatalysis
Round 1
Reviewer 1 Report
The minireview by da Silva et. al discusses the asymmetric synthesis of antiviral drugs by organocatalysis. Overall, this is a very good and high-quality review on a hot topic.
The review is nicely structured by antiviral drugs and it gives good examples of different organocatalyst classes that have been successfully applied for the corresponding synthetic route. It also compares the organocatalysis to traditional synthetic routes that use e.g. metals for asymmetric synthesis.
I feel this review can be published as it is. I have no further remarks.
Reviewer 2 Report
The (mini)review manuscript titled “Advances on Greener Asymmetric Synthesis of Antiviral Drugs via organocatalysis” describes a series of synthetic pathways used for the synthesis of some selected antiviral drugs. As expected, the authors focused the attention on the synthetic steps involving the formation of chiral centers. Interestingly, the authors also reported a table (Table 1) with some antiviral drugs, highlighting the synthetic strategy used for obtaining enantiomeric pure derivatives.
The manuscript is well written and the described syntheses appear updated.
Interestingly, the authors also described the story behind the discovery of greener and better synthetic pathways, highlighting strength and weakness of the reported procedures.
