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Pharmaceuticals
Volume 14
Issue 3
10.3390/ph14030204
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Review

Pharmacogenetics of Carbamazepine and Valproate: Focus on Polymorphisms of Drug Metabolizing Enzymes and Transporters

by
Teresa Iannaccone
1,
Carmine Sellitto
1,2,*,
Valentina Manzo
1,2,
Francesca Colucci
1,
Valentina Giudice
1,
Berenice Stefanelli
1,
Antonio Iuliano
1,
Giulio Corrivetti
3 and
Amelia Filippelli
1,2
1
Department of Medicine, Surgery and Dentistry “Scuola Medica Salernitana”, University of Salerno, 84081 Baronissi, Italy
2
Clinical Pharmacology and Pharmacogenetics Unit, University Hospital “San Giovanni di Dio e Ruggi d’Aragona”, 84131 Salerno, Italy
3
European Biomedical Research Institute of Salerno (EBRIS), 84125 Salerno, Italy
*
Author to whom correspondence should be addressed.
Pharmaceuticals 2021, 14(3), 204; https://doi.org/10.3390/ph14030204
Submission received: 11 January 2021 / Revised: 24 February 2021 / Accepted: 25 February 2021 / Published: 1 March 2021
(This article belongs to the Special Issue The Pharmacogenomics of Mood Stabilizers)
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Abstract

Pharmacogenomics can identify polymorphisms in genes involved in drug pharmacokinetics and pharmacodynamics determining differences in efficacy and safety and causing inter-individual variability in drug response. Therefore, pharmacogenomics can help clinicians in optimizing therapy based on patient’s genotype, also in psychiatric and neurological settings. However, pharmacogenetic screenings for psychotropic drugs are not routinely employed in diagnosis and monitoring of patients treated with mood stabilizers, such as carbamazepine and valproate, because their benefit in clinical practice is still controversial. In this review, we summarize the current knowledge on pharmacogenetic biomarkers of these anticonvulsant drugs.
Keywords: pharmacogenomics; carbamazepine; valproate; mood stabilizers pharmacogenomics; carbamazepine; valproate; mood stabilizers

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MDPI and ACS Style

Iannaccone, T.; Sellitto, C.; Manzo, V.; Colucci, F.; Giudice, V.; Stefanelli, B.; Iuliano, A.; Corrivetti, G.; Filippelli, A. Pharmacogenetics of Carbamazepine and Valproate: Focus on Polymorphisms of Drug Metabolizing Enzymes and Transporters. Pharmaceuticals 2021, 14, 204. https://doi.org/10.3390/ph14030204

AMA Style

Iannaccone T, Sellitto C, Manzo V, Colucci F, Giudice V, Stefanelli B, Iuliano A, Corrivetti G, Filippelli A. Pharmacogenetics of Carbamazepine and Valproate: Focus on Polymorphisms of Drug Metabolizing Enzymes and Transporters. Pharmaceuticals. 2021; 14(3):204. https://doi.org/10.3390/ph14030204

Chicago/Turabian Style

Iannaccone, Teresa, Carmine Sellitto, Valentina Manzo, Francesca Colucci, Valentina Giudice, Berenice Stefanelli, Antonio Iuliano, Giulio Corrivetti, and Amelia Filippelli. 2021. "Pharmacogenetics of Carbamazepine and Valproate: Focus on Polymorphisms of Drug Metabolizing Enzymes and Transporters" Pharmaceuticals 14, no. 3: 204. https://doi.org/10.3390/ph14030204

APA Style

Iannaccone, T., Sellitto, C., Manzo, V., Colucci, F., Giudice, V., Stefanelli, B., Iuliano, A., Corrivetti, G., & Filippelli, A. (2021). Pharmacogenetics of Carbamazepine and Valproate: Focus on Polymorphisms of Drug Metabolizing Enzymes and Transporters. Pharmaceuticals, 14(3), 204. https://doi.org/10.3390/ph14030204

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