Identification of New L-Heptanoylphosphatidyl Inositol Pentakisphosphate Derivatives Targeting the Interaction with HIV-1 Gag by Molecular Modelling Studies
, Belgin Sever 2,4,†, Esra Ayan 3, Mustafa Can 2,5, Hasan DeMirci 3, Masami Otsuka 1,2, Amaç Fatih TuYuN 6,*, Hiroshi Tateishi 2,* and Mikako Fujita 2,*
Lucia Pintilie
Round 1
Reviewer 1 Report
Comments for author File: 
Comments.pdf
Author Response
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Author Response File: Author Response.pdf
Reviewer 2 Report
The work presented to me for review concerns the description of the interaction of new L-Heptanoylphosphatidyl Inositol Pen- 2 takisphosphate derivatives with HIV-1 Gag using molecular modeling. The authors first describe the results for 8 derivatives, and then on their basis create a library containing up to 213 compounds. The work is prepared carefully, reliably, and the results are properly described. The description of the experiment does not raise my reservations either. I believe that the publication is innovative. I only have a few minor comments:
- I suggest increasing the font size in Figure 1A as it is now hard to read.
- Line 134 - the reference to Figure 1 should not be written in red
- Figure 3 is too small compared to the rest of the text. Should be edited to make it more readable.
Author Response
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Author Response File: Author Response.pdf
