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Volume 15
Issue 10
10.3390/ph15101283
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Review

Strategies for Improving Peptide Stability and Delivery

by
Othman Al Musaimi
1,*,†,
Lucia Lombardi
1,*,†,
Daryl R. Williams
1 and
Fernando Albericio
2,3
1
Surfaces and Particle Engineering Laboratory, Department of Chemical Engineering, Imperial College London, London SW7 2AZ, UK
2
School of Chemistry and Physics, University of KwaZulu-Natal, Durban 4001, South Africa
3
CIBER-BBN, Networking Centre on Bioengineering, Biomaterials and Nanomedicine and Department of Organic Chemistry, University of Barcelona, 08028 Barcelona, Spain
*
Authors to whom correspondence should be addressed.
†
These authors contributed equally to this work.
Pharmaceuticals 2022, 15(10), 1283; https://doi.org/10.3390/ph15101283
Submission received: 2 October 2022 / Revised: 14 October 2022 / Accepted: 17 October 2022 / Published: 19 October 2022
(This article belongs to the Special Issue Feature Reviews in Biopharmaceuticals)
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Abstract

Peptides play an important role in many fields, including immunology, medical diagnostics, and drug discovery, due to their high specificity and positive safety profile. However, for their delivery as active pharmaceutical ingredients, delivery vectors, or diagnostic imaging molecules, they suffer from two serious shortcomings: their poor metabolic stability and short half-life. Major research efforts are being invested to tackle those drawbacks, where structural modifications and novel delivery tactics have been developed to boost their ability to reach their targets as fully functional species. The benefit of selected technologies for enhancing the resistance of peptides against enzymatic degradation pathways and maximizing their therapeutic impact are also reviewed. Special note of cell-penetrating peptides as delivery vectors, as well as stapled modified peptides, which have demonstrated superior stability from their parent peptides, are reported.
Keywords: peptides; cell-penetrating peptides; stapled peptides; stitched peptides; hydrogel; self-assembled peptides peptides; cell-penetrating peptides; stapled peptides; stitched peptides; hydrogel; self-assembled peptides

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MDPI and ACS Style

Al Musaimi, O.; Lombardi, L.; Williams, D.R.; Albericio, F. Strategies for Improving Peptide Stability and Delivery. Pharmaceuticals 2022, 15, 1283. https://doi.org/10.3390/ph15101283

AMA Style

Al Musaimi O, Lombardi L, Williams DR, Albericio F. Strategies for Improving Peptide Stability and Delivery. Pharmaceuticals. 2022; 15(10):1283. https://doi.org/10.3390/ph15101283

Chicago/Turabian Style

Al Musaimi, Othman, Lucia Lombardi, Daryl R. Williams, and Fernando Albericio. 2022. "Strategies for Improving Peptide Stability and Delivery" Pharmaceuticals 15, no. 10: 1283. https://doi.org/10.3390/ph15101283

APA Style

Al Musaimi, O., Lombardi, L., Williams, D. R., & Albericio, F. (2022). Strategies for Improving Peptide Stability and Delivery. Pharmaceuticals, 15(10), 1283. https://doi.org/10.3390/ph15101283

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