Analgesic and Anesthetic Efficacy of Rocuronium/Sugammadex in Otorhinolaryngologic Surgery: A Propensity Score-Matched Analysis
Abstract
:1. Introduction
2. Results
3. Discussion
Limitations
4. Materials and Methods
4.1. Data Collection and Study Design
4.2. Anesthesia Management
4.3. Primary and Secondary Outcomes
4.4. Statistical Analysis
5. Conclusions
Supplementary Materials
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
References
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Variables (Unit) | N(%)/Median (IQR) | Cisatracurium /Neostigmine n = 119 | Rocuronium /Sugammadex n = 119 | p-Value |
---|---|---|---|---|
Sex | ||||
Female | 67 (28.2%) | 35 (29.4%) | 32 (26.9%) | 0.665 |
Male | 171 (71.8%) | 84 (70.6%) | 87 (73.1%) | |
Age | 43.0 (31.0–56.0) | 43.0 (29.0–57.0) | 43.0 (33.0–54.0) | 0.786 |
Body weight (kg) | 75.0 (65.0–86.0) | 75.0 (67.0–87.0) | 75.0 (64.0–86.0) | 0.649 |
ASA classification | ||||
Ⅰ | 20 (8.4%) | 13 (10.9%) | 7 (5.9%) | 0.374 |
Ⅱ | 181 (76.1%) | 88 (73.9%) | 93 (78.2%) | |
Ⅲ | 37 (15.5%) | 18 (15.1%) | 19 (16.0%) | |
Apfel score | ||||
0 | 27 (16.7%) | 11 (13.9%) | 16 (19.3%) | 0.822 |
1 | 55 (34.0%) | 27 (34.2%) | 28 (33.7%) | |
2 | 53 (32.7%) | 28 (35.4%) | 25 (30.1%) | |
3 | 24 (14.8%) | 11 (13.9%) | 13 (15.7%) | |
4 | 3 (1.9%) | 2 (2.5%) | 1 (1.2%) | |
Hypertension | ||||
No | 195 (81.9%) | 98 (82.4%) | 97 (81.5%) | 0.866 |
Yes | 43 (18.1%) | 21 (17.6%) | 22 (18.5%) | |
DM | (-) | (-) | (-) | |
No | 218 (90.3%) | 106 (89.1%) | 109 (91.6%) | 0.510 |
Yes | 23 (9.7%) | 13 (10.9%) | 10 (8.4%) | |
CVA | ||||
No | 237 (99.6%) | 118 (99.2%) | 119 (100.0%) | 1.000 |
Yes | 1 (0.4%) | 1 (0.8%) | 0 (0.0%) | |
Surgical indication for otorhinolaryngologic surgery | ||||
Multiple sinusectomy | 38 (16.0%) | 17 (14.3%) | 21 (17.6%) | 0.830 |
Pansinusectomy | 20 (8.4%) | 12 (10.1%) | 8 (6.7%) | |
Septomeatal plasty | 34 (14.3%) | 18 (15.1%) | 16 (13.4%) | |
Uvulopalatopharyngoplasty | 118 (49.6%) | 59 (49.6%) | 59 (49.6%) | |
Oral tumor or oropharynx excision | 28 (11.8%) | 13 (10.9%) | 15 (12.6%) |
Variables (Unit) | N(%)/Median (IQR) | Cisatracurium /Neostigmine n = 119 | Rocuronium /Sugammadex n = 119 | p-Value |
---|---|---|---|---|
Intraoperative | ||||
Duration of anesthesia (h) | 3.33 (2.35–6.17) | 2.82 (2.08–4.33) | 4.63 (2.92–6.75) | <0.001 |
Baseline MAP | 97.2 (88.7–106.2) | 98.7 (89.7–107.5) | 95.8 (87.8–104.7) | 0.354 |
Percentage of † MAP > 120% (%) | 1.4 (0–6.4) | 1.9 (0–6.5) | 1.4 (0–5.9) | 0.325 |
Fluid mL/kg/h | 2.13 (1.63–2.67) | 2.22 (1.66–2.89) | 2.08 (1.50–2.56) | 0.064 |
Sevoflurane consumption (mL/h) | 0.20 (0.18–0.21) | 0.21 (0.19–0.24) | 0.18 (0.16–0.19) | 0.009 |
†† Intraoperative MME (mg/kg/h) | 0.073 (0.056–0.102) | 0.076 (0.057–0.116) | 0.067 (0.056–0.092) | 0.035 |
Labetalol (mg) | 0 (0–2.5) | 0 (0–2.5) | 0 (0–5.0) | 0.002 |
Nicardipine (mg) | 0 (0–1.0) | 0 (0–0.5) | 0 (0–1.0) | 0.245 |
Postoperative | ||||
Postoperative parecoxib (Dynastat®) | 36 (15%) | 21 (18%) | 15 (13%) | 0.278 |
†† Postoperative MME (mg/kg/h) | 0 (0–0) | 0 (0–0) | 0 (0–0) | 0.054 |
VAS at ward | 2 (2–3) | 2 (2–3) | 2 (1–3) | 0.086 |
PONV at ward | 1 (0.4%) | 1 (0.8%) | 0 (0%) | 1.0 |
Blood loss (mL) | 0 (0–100) | 0 (0–50) | 0 (0–100) | 0.507 |
Extubation time (min) | 5 (5–10) | 5 (5–10) | 5 (5–10) | 0.176 |
LOS (day) | 4 (2–6) | 4 (3–6) | 4 (2–6) | 0.553 |
Percentage of delayed extubation (%) | 3 (1.3%) | 3 (2.5%) | 0 (0%) | 0.111 |
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Wu, E.-B.; Hung, C.-T.; Luo, S.-D.; Wu, S.-C.; Lee, T.-Y.; Chin, J.-C.; Tsai, P.-N.; Yang, J.C.-S. Analgesic and Anesthetic Efficacy of Rocuronium/Sugammadex in Otorhinolaryngologic Surgery: A Propensity Score-Matched Analysis. Pharmaceuticals 2022, 15, 894. https://doi.org/10.3390/ph15070894
Wu E-B, Hung C-T, Luo S-D, Wu S-C, Lee T-Y, Chin J-C, Tsai P-N, Yang JC-S. Analgesic and Anesthetic Efficacy of Rocuronium/Sugammadex in Otorhinolaryngologic Surgery: A Propensity Score-Matched Analysis. Pharmaceuticals. 2022; 15(7):894. https://doi.org/10.3390/ph15070894
Chicago/Turabian StyleWu, En-Bo, Chao-Ting Hung, Sheng-Dean Luo, Shao-Chun Wu, Tsung-Yang Lee, Jo-Chi Chin, Peng-Neng Tsai, and Johnson Chia-Shen Yang. 2022. "Analgesic and Anesthetic Efficacy of Rocuronium/Sugammadex in Otorhinolaryngologic Surgery: A Propensity Score-Matched Analysis" Pharmaceuticals 15, no. 7: 894. https://doi.org/10.3390/ph15070894