First Evidence of Activity of Enfortumab Vedotin on Brain Metastases in Urothelial Cancer Patients
Abstract
:1. Introduction
- (1)
- CNS metastases have been clinically stable for at least six weeks prior to screening.
- (2)
- If steroid treatment was required for CNS metastases, the subject should be on a stable dose (≤20 mg/day) of prednisone or equivalent for at least two weeks.
- (3)
- Baseline scans show no evidence of new or enlarged brain metastases.
- (4)
- The subject does not have leptomeningeal disease [10].
2. Case Presentations
2.1. Case 1
2.2. Case 2
2.3. Case 3
3. Discussion
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
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Vulsteke, C.; De Cocker, L.; Gómez de Liaño, A.; Montesdeoca, C.; De Meulenaere, A.; Croes, L.; Delombaerde, D.; Szabados, B.; Powles, T. First Evidence of Activity of Enfortumab Vedotin on Brain Metastases in Urothelial Cancer Patients. Pharmaceuticals 2023, 16, 375. https://doi.org/10.3390/ph16030375
Vulsteke C, De Cocker L, Gómez de Liaño A, Montesdeoca C, De Meulenaere A, Croes L, Delombaerde D, Szabados B, Powles T. First Evidence of Activity of Enfortumab Vedotin on Brain Metastases in Urothelial Cancer Patients. Pharmaceuticals. 2023; 16(3):375. https://doi.org/10.3390/ph16030375
Chicago/Turabian StyleVulsteke, Christof, Laurens De Cocker, Alfonso Gómez de Liaño, Cristina Montesdeoca, Astrid De Meulenaere, Lieselot Croes, Danielle Delombaerde, Bernadett Szabados, and Thomas Powles. 2023. "First Evidence of Activity of Enfortumab Vedotin on Brain Metastases in Urothelial Cancer Patients" Pharmaceuticals 16, no. 3: 375. https://doi.org/10.3390/ph16030375