The Adapted POM Analysis of Avenanthramides In Silico

Round 1

Reviewer 1 Report

The article brings into discussion the avenanthramides (AVNs), very promising secondary oat metabolites with biological effects as antioxidant, antiproliferative, anti-inflammatory, and hepatoprotective.
The fact that we have limited information available on the pharmacokinetic profile, potential toxicity, and metabolism of individual AVNs, the study aims to provide a more in-depth analysis of these compounds, focusing on drug score, toxicity, bioactivity, and favorable ADME properties, using POM analysis, an efficient bioinformatic approach to assess the basic physical-chemical parameters of the molecules and predict bioactivity, toxicity, drug-likeness parameters and prediction of ADME parameters.
 
The study may present interest to oat breeders, functional food manufacturers, and the scientific community interested in the therapeutic potential of AVNs because they are low toxic compounds with low risk of tumorigenicity and mutagenicity.

Author Response

Thanks for this review.  No reviewer comment to response. Not uploaded file. Sincerely yours, corresponding author.

Reviewer 2 Report

This well written paper provides a comprehensive assessment of AVN through the POM approach and has generated interest in the therapeutic potential of AVN among oat breeders, functional food manufacturers and the scientific community. Detailed recommendations are shown in word .

Comments for author File: Comments.pdf

overall fine, minor English language edit needed

Author Response

Dear Editor and reviewers,

Thank you for providing feedback on our manuscript and for the insightful comments. We have incorporated all the suggestions. Those changes are highlighted within the manuscript. Please see below, for a point-by-point response to the comments. All page numbers refer to the revised manuscript file with tracked changes.

Comment 1: On page 1. Introduction, it is suggested that the authors start with a general background on AVNs and then narrow down to the relevant topics that will be pursued in the thesis and the related POM methods. Perhaps this section could be improved.

The section Introduction has been improved according to the suggestion (pages 1-3) and several novel references have been added to a list of references (pages 11-12).

Comment 2: In addition, consider replacing the x and y axes in figures2 in your text with more accurate numbers and changing 0,00 in figures2 to 0.00, i.e., replacing “, ”in the figure2 with “.” .

Replacing the x and y axes has been considered and Figure 2 has been updated accordingly. Furthermore, the decimal separator has been corrected in Figure 2 (page 6).

Comment 3: Conclusions needs more in it, as it's more of an afterthought. The authors are suggested to highlight important findings and include afterthought of this work.

Conclusions have been extended by highlighting the most important findings and afterthoughts have been included (page 11).

We look forward to hearing from you regarding our submission and to responding to any further questions and comments you may have.

Best regards,

assoc Prof. Tibor Maliar, Ph.D.