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Volume 16
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10.3390/ph16050776
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Review

Carboxymethylated Gums and Derivatization: Strategies and Significance in Drug Delivery and Tissue Engineering

by
Madhuri Baghel
1,
Kalyani Sakure
2,
Tapan Kumar Giri
3,
Sabyasachi Maiti
4,
Kartik T. Nakhate
5,
Shreesh Ojha
6,
Charu Sharma
7,
Yogeeta Agrawal
8,
Sameer Goyal
5,* and
Hemant Badwaik
1,*
1
Department of Pharmaceutical Chemistry, Shri Shankaracharya Institute of Pharmaceutical Sciences and Research, Junwani, Bhilai 490020, Chhattisgarh, India
2
Department of Pharmaceutics, Rungta College of Pharmaceutical Sciences and Research, Kurud Road, Kohka, Bhilai 490024, Chhattisgarh, India
3
Department of Pharmaceutical Technology, Jadavpur University, Kolkata 700032, West Bengal, India
4
Department of Pharmacy, Indira Gandhi National Tribal University, Amarkantak 484887, Madhya Pradesh, India
5
Department of Pharmacology, Shri Vile Parle Kelavani Mandal’s Institute of Pharmacy, Dhule 424001, Maharashtra, India
6
Department of Pharmacology and Therapeutics, College of Medicine and Health Sciences, United Arab Emirates University, Al Ain P.O. Box 15551, United Arab Emirates
7
Department of Internal Medicine, College of Medicine and Health Sciences, United Arab Emirates University, Al Ain P.O. Box 15551, United Arab Emirates
8
Department of Pharmaceutics, Shri Vile Parle Kelavani Mandal’s Institute of Pharmacy, Dhule 424001, Maharashtra, India
*
Authors to whom correspondence should be addressed.
Pharmaceuticals 2023, 16(5), 776; https://doi.org/10.3390/ph16050776
Submission received: 7 April 2023 / Revised: 30 April 2023 / Accepted: 4 May 2023 / Published: 22 May 2023
(This article belongs to the Section Pharmaceutical Technology)
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Abstract

Natural polysaccharides have been widely exploited in drug delivery and tissue engineering research. They exhibit excellent biocompatibility and fewer adverse effects; however, it is challenging to assess their bioactivities to that of manufactured synthetics because of their intrinsic physicochemical characteristics. Studies showed that the carboxymethylation of polysaccharides considerably increases the aqueous solubility and bioactivities of inherent polysaccharides and offers structural diversity, but it also has some limitations that can be resolved by derivatization or the grafting of carboxymethylated gums. The swelling ratio, flocculation capacity, viscosity, partition coefficient, metal absorption properties, and thermosensitivity of natural polysaccharides have been improved as a result of these changes. In order to create better and functionally enhanced polysaccharides, researchers have modified the structures and properties of carboxymethylated gums. This review summarizes the various ways of modifying carboxymethylated gums, explores the impact that molecular modifications have on their physicochemical characteristics and bioactivities, and sheds light on various applications for the derivatives of carboxymethylated polysaccharides.
Keywords: carboxymethylated gums; derivatization; drug delivery; tissue engineering carboxymethylated gums; derivatization; drug delivery; tissue engineering

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MDPI and ACS Style

Baghel, M.; Sakure, K.; Giri, T.K.; Maiti, S.; Nakhate, K.T.; Ojha, S.; Sharma, C.; Agrawal, Y.; Goyal, S.; Badwaik, H. Carboxymethylated Gums and Derivatization: Strategies and Significance in Drug Delivery and Tissue Engineering. Pharmaceuticals 2023, 16, 776. https://doi.org/10.3390/ph16050776

AMA Style

Baghel M, Sakure K, Giri TK, Maiti S, Nakhate KT, Ojha S, Sharma C, Agrawal Y, Goyal S, Badwaik H. Carboxymethylated Gums and Derivatization: Strategies and Significance in Drug Delivery and Tissue Engineering. Pharmaceuticals. 2023; 16(5):776. https://doi.org/10.3390/ph16050776

Chicago/Turabian Style

Baghel, Madhuri, Kalyani Sakure, Tapan Kumar Giri, Sabyasachi Maiti, Kartik T. Nakhate, Shreesh Ojha, Charu Sharma, Yogeeta Agrawal, Sameer Goyal, and Hemant Badwaik. 2023. "Carboxymethylated Gums and Derivatization: Strategies and Significance in Drug Delivery and Tissue Engineering" Pharmaceuticals 16, no. 5: 776. https://doi.org/10.3390/ph16050776

APA Style

Baghel, M., Sakure, K., Giri, T. K., Maiti, S., Nakhate, K. T., Ojha, S., Sharma, C., Agrawal, Y., Goyal, S., & Badwaik, H. (2023). Carboxymethylated Gums and Derivatization: Strategies and Significance in Drug Delivery and Tissue Engineering. Pharmaceuticals, 16(5), 776. https://doi.org/10.3390/ph16050776

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