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Pharmaceuticals
Volume 16
Issue 9
10.3390/ph16091242
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Review

Inflammation in Coronary Atherosclerosis: Insights into Pathogenesis and Therapeutic Potential of Anti-Inflammatory Drugs

by
Clara Salles Figueiredo
1,2,*,
Elias Soares Roseira
2,
Tainá Teixeira Viana
1,2,
Marcelo Augusto Duarte Silveira
1,
Rodrigo Morel Vieira de Melo
1,2,
Miguel Godeiro Fernandez
2,
Livia Maria Goes Lemos
2 and
Luiz Carlos Santana Passos
1,2
1
Programa de Pós Graduação em Medicina e Saúde (Graduate Program in Medicine and Health), Federal University of Bahia, Salvador 40110-060, BA, Brazil
2
Hospital Ana Nery, Salvador 40301-155, BA, Brazil
*
Author to whom correspondence should be addressed.
Pharmaceuticals 2023, 16(9), 1242; https://doi.org/10.3390/ph16091242
Submission received: 25 July 2023 / Revised: 12 August 2023 / Accepted: 16 August 2023 / Published: 1 September 2023
(This article belongs to the Special Issue Cardiac Electrophysiology and Pharmacology)
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Abstract

Atherosclerosis is a lipid-driven immune-inflammatory disease that affects the arteries, leading to multifocal plaque development. The inflammatory process involves the activation of immune cells and various inflammatory pathways. Anti-inflammatory drugs have been shown to be effective in reducing cardiovascular events in individuals with coronary disease. However, their use is still limited due to concerns about long-term follow-up, cost-effectiveness, adverse effects, and the identification of the ideal patient profile to obtain maximum benefits. This review aims to improve the understanding of inflammation in coronary atherosclerosis and explore potential therapeutic interventions, encompassing both traditional and non-traditional anti-inflammatory approaches. By addressing these concepts, we seek to contribute to the advancement of knowledge about this type of treatment for coronary artery disease.
Keywords: coronary artery disease; anti-inflammatories; myocardial ischemia coronary artery disease; anti-inflammatories; myocardial ischemia

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MDPI and ACS Style

Figueiredo, C.S.; Roseira, E.S.; Viana, T.T.; Silveira, M.A.D.; de Melo, R.M.V.; Fernandez, M.G.; Lemos, L.M.G.; Passos, L.C.S. Inflammation in Coronary Atherosclerosis: Insights into Pathogenesis and Therapeutic Potential of Anti-Inflammatory Drugs. Pharmaceuticals 2023, 16, 1242. https://doi.org/10.3390/ph16091242

AMA Style

Figueiredo CS, Roseira ES, Viana TT, Silveira MAD, de Melo RMV, Fernandez MG, Lemos LMG, Passos LCS. Inflammation in Coronary Atherosclerosis: Insights into Pathogenesis and Therapeutic Potential of Anti-Inflammatory Drugs. Pharmaceuticals. 2023; 16(9):1242. https://doi.org/10.3390/ph16091242

Chicago/Turabian Style

Figueiredo, Clara Salles, Elias Soares Roseira, Tainá Teixeira Viana, Marcelo Augusto Duarte Silveira, Rodrigo Morel Vieira de Melo, Miguel Godeiro Fernandez, Livia Maria Goes Lemos, and Luiz Carlos Santana Passos. 2023. "Inflammation in Coronary Atherosclerosis: Insights into Pathogenesis and Therapeutic Potential of Anti-Inflammatory Drugs" Pharmaceuticals 16, no. 9: 1242. https://doi.org/10.3390/ph16091242

APA Style

Figueiredo, C. S., Roseira, E. S., Viana, T. T., Silveira, M. A. D., de Melo, R. M. V., Fernandez, M. G., Lemos, L. M. G., & Passos, L. C. S. (2023). Inflammation in Coronary Atherosclerosis: Insights into Pathogenesis and Therapeutic Potential of Anti-Inflammatory Drugs. Pharmaceuticals, 16(9), 1242. https://doi.org/10.3390/ph16091242

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