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Volume 17
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10.3390/ph17081063
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Review

Unearthing the Potential Therapeutic Effects of Oxyresveratrol Based on Intrinsic Links between Pharmacological Effects: Implications for the Gut–Liver–Brain Axis

by
Lijuan Zhao
1,2,3,4,
Yan Duan
1,2,3,
Zhaoxing Li
2,3,5,
Juan Li
1,2,3 and
Shunxiang Li
1,2,3,*
1
School of Pharmacy, Hunan University of Chinese Medicine, Changsha 410208, China
2
Hunan Engineering Technology Research Center for Bioactive Substance Discovery of Chinese Medicine, Changsha 410208, China
3
Hunan Province Sino-US International Joint Research Center for Therapeutic Drugs of Senile Degenerative Diseases, Changsha 410208, China
4
College of Biology and Food Engineering, Huaihua University, Huaihua 418000, China
5
School of Pharmacy, China Pharmaceutical University, Nanjing 210009, China
*
Author to whom correspondence should be addressed.
Pharmaceuticals 2024, 17(8), 1063; https://doi.org/10.3390/ph17081063
Submission received: 19 March 2024 / Revised: 9 August 2024 / Accepted: 11 August 2024 / Published: 13 August 2024
(This article belongs to the Special Issue Exploring Natural Metabolites to Identify Novel Potential Therapeutic Agents)
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Abstract

Oxyresveratrol is a stilbene compound with a simple chemical structure and various therapeutic potentials. This study summarized and analyzed the multiple pharmacological effects and mechanisms of oxyresveratrol, identifying its prominent performance in neuroprotection, hepatoprotection, and anti-inflammatory activities in the intestines. By integrating the pharmacological effects of oxyresveratrol with insights from the network pharmacology and molecular docking of its interactions with targets linked to gut–liver–brain axis disorders, it has been shown that oxyresveratrol may hold promise for the treatment of gut–liver–brain axis-related disorders. The synergistic effect between various mechanisms has inspired further research and the development of oxyresveratrol’s application value.
Keywords: oxyresveratrol; stilbene compounds; molecular docking; gut–liver–brain axis; synergistic effect oxyresveratrol; stilbene compounds; molecular docking; gut–liver–brain axis; synergistic effect

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MDPI and ACS Style

Zhao, L.; Duan, Y.; Li, Z.; Li, J.; Li, S. Unearthing the Potential Therapeutic Effects of Oxyresveratrol Based on Intrinsic Links between Pharmacological Effects: Implications for the Gut–Liver–Brain Axis. Pharmaceuticals 2024, 17, 1063. https://doi.org/10.3390/ph17081063

AMA Style

Zhao L, Duan Y, Li Z, Li J, Li S. Unearthing the Potential Therapeutic Effects of Oxyresveratrol Based on Intrinsic Links between Pharmacological Effects: Implications for the Gut–Liver–Brain Axis. Pharmaceuticals. 2024; 17(8):1063. https://doi.org/10.3390/ph17081063

Chicago/Turabian Style

Zhao, Lijuan, Yan Duan, Zhaoxing Li, Juan Li, and Shunxiang Li. 2024. "Unearthing the Potential Therapeutic Effects of Oxyresveratrol Based on Intrinsic Links between Pharmacological Effects: Implications for the Gut–Liver–Brain Axis" Pharmaceuticals 17, no. 8: 1063. https://doi.org/10.3390/ph17081063

APA Style

Zhao, L., Duan, Y., Li, Z., Li, J., & Li, S. (2024). Unearthing the Potential Therapeutic Effects of Oxyresveratrol Based on Intrinsic Links between Pharmacological Effects: Implications for the Gut–Liver–Brain Axis. Pharmaceuticals, 17(8), 1063. https://doi.org/10.3390/ph17081063

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