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Volume 17
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Review

Icariin as a Treatment Proposal in Mammalian Reproduction

by
Manuel Sánchez-Gutiérrez
1,
Aleli Julieta Izquierdo-Vega
1,
Eduardo Osiris Madrigal-Santillán
1,
Claudia Velázquez-González
2 and
Jeannett Alejandra Izquierdo-Vega
1,*
1
Academic Area of Medicine, Institute of Health Sciences, Autonomous University of the State of Hidalgo, Ex-Hacienda la Concepción, Tilcuautla 42160, Mexico
2
Academic Area of Pharmacy, Institute of Health Sciences, Autonomous University of the State of Hidalgo, Ex-Hacienda la Concepción, Tilcuautla 42160, Mexico
*
Author to whom correspondence should be addressed.
Pharmaceuticals 2024, 17(9), 1104; https://doi.org/10.3390/ph17091104
Submission received: 19 July 2024 / Revised: 16 August 2024 / Accepted: 19 August 2024 / Published: 23 August 2024
(This article belongs to the Special Issue Plant-Derived Natural Compounds as Bioactive Molecules with Beneficial Effects on Human Health)
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Abstract

Icariin (ICA), one of the main active components of Herba Epimedii, is a natural prenylated flavonol glycoside that possesses a wide range of pharmacological effects, including antioxidant, antiosteoporotic, anti-aging, neuroprotective, immunomodulatory, antitumor, and aphrodisiac effects, and prevents numerous health disorders, such as cardiovascular diseases, osteoporosis, cancer, sexual dysfunction, menstrual disorders, neurodegenerative diseases, asthma, chronic inflammation, and diabetes. In the reproductive system, it has been observed that ICA may play a role in preserving fertility by regulating different signalling pathways, such as PI3K/AKT, which improves ovarian function, and ERα/Nrf2, which enhances testicular function and prevents ROS generation. In contrast, regulating the NF/kB signalling pathway causes anti-inflammatory effects, reducing spontaneous abortions. In this study, we review and examine the relevant literature on the therapeutic potential of ICA in reproduction, highlight the various mechanisms of action and limitations for the therapeutic applications of ICA, and summarise and highlight the existing preclinical research on its effects on male and female reproduction.
Keywords: icariin; male infertility; female infertility; reproductive icariin; male infertility; female infertility; reproductive

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MDPI and ACS Style

Sánchez-Gutiérrez, M.; Izquierdo-Vega, A.J.; Madrigal-Santillán, E.O.; Velázquez-González, C.; Izquierdo-Vega, J.A. Icariin as a Treatment Proposal in Mammalian Reproduction. Pharmaceuticals 2024, 17, 1104. https://doi.org/10.3390/ph17091104

AMA Style

Sánchez-Gutiérrez M, Izquierdo-Vega AJ, Madrigal-Santillán EO, Velázquez-González C, Izquierdo-Vega JA. Icariin as a Treatment Proposal in Mammalian Reproduction. Pharmaceuticals. 2024; 17(9):1104. https://doi.org/10.3390/ph17091104

Chicago/Turabian Style

Sánchez-Gutiérrez, Manuel, Aleli Julieta Izquierdo-Vega, Eduardo Osiris Madrigal-Santillán, Claudia Velázquez-González, and Jeannett Alejandra Izquierdo-Vega. 2024. "Icariin as a Treatment Proposal in Mammalian Reproduction" Pharmaceuticals 17, no. 9: 1104. https://doi.org/10.3390/ph17091104

APA Style

Sánchez-Gutiérrez, M., Izquierdo-Vega, A. J., Madrigal-Santillán, E. O., Velázquez-González, C., & Izquierdo-Vega, J. A. (2024). Icariin as a Treatment Proposal in Mammalian Reproduction. Pharmaceuticals, 17(9), 1104. https://doi.org/10.3390/ph17091104

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