Analgesic Effect of Human Placenta Hydrolysate on CFA-Induced Inflammatory Pain in Mice
Abstract
:1. Introduction
2. Results
2.1. Antinociceptive Effect of HPH in CFA-Induced Cold, Mechanical Allodynia
2.2. HPH Decreases Paw Thickness and Pro-Inflammatory Cytokines Increased by CFA Injection
2.3. Ameliorating Effect of HPH on CFA-Induced Histological Damage
2.4. mRNA Expression of Pro-Inflammatory Cytokine Using qPCR in Spinal Cord and Levels of Cytokine of Serum
2.5. Glial Cell Activation
2.6. Protein Expression of Pro-Inflammatory Cytokines Using Western Blot in Spinal Cord
2.7. Decreased Expression of Phosphorylated Akt in the Spinal Cord after HPH Administration
3. Discussion
4. Materials and Methods
4.1. Chemicals
4.2. Animals
4.3. Establishment of an Inflammatory Pain Model Using CFA Injection
4.4. Behavioral Assessment
4.5. Gene Expression Using Gene-Specific Primers
4.6. Western Blot
4.7. Enzyme-Linked Immunosorbent Assay (ELISA)
4.8. Hematoxylin and Eosin Staining and Inflammation Scoring
4.9. Immunohistochemistry Analysis
4.10. Statistical Analysis
5. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
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Park, K.-T.; Jo, H.; Jeon, S.-H.; Jeong, K.; Im, M.; Kim, J.-W.; Jung, J.-P.; Jung, H.C.; Lee, J.h.; Kim, W. Analgesic Effect of Human Placenta Hydrolysate on CFA-Induced Inflammatory Pain in Mice. Pharmaceuticals 2024, 17, 1179. https://doi.org/10.3390/ph17091179
Park K-T, Jo H, Jeon S-H, Jeong K, Im M, Kim J-W, Jung J-P, Jung HC, Lee Jh, Kim W. Analgesic Effect of Human Placenta Hydrolysate on CFA-Induced Inflammatory Pain in Mice. Pharmaceuticals. 2024; 17(9):1179. https://doi.org/10.3390/ph17091179
Chicago/Turabian StylePark, Keun-Tae, Heejoon Jo, So-Hyun Jeon, Kyeongsoo Jeong, Minju Im, Jae-Won Kim, Jong-Pil Jung, Hoe Chang Jung, Jae hun Lee, and Woojin Kim. 2024. "Analgesic Effect of Human Placenta Hydrolysate on CFA-Induced Inflammatory Pain in Mice" Pharmaceuticals 17, no. 9: 1179. https://doi.org/10.3390/ph17091179