Spotlight on Human LL-37, an Immunomodulatory Peptide with Promising Cell-Penetrating Properties
Abstract
:1. Introduction
2. Defensins
3. Cathelicidins
4. Effects of LL-37 on Prokaryotes
4.1. Structure of LL-37 and Biophysical Studies
4.2. Mode of Action of LL-37 on Prokaryotes
4.3. Interaction of LL-37 Derivatives with Lipid Bilayers
4.4. Mechanisms of Resistance of Prokaryotes to LL-37
4.5. Effect of LL-37 on Biofilms
5. Effects of LL-37 on Eukaryotic Cells
6. LL-37, a Cell-Penetrating Peptide
7. Conclusions and Perspectives
Abbreviations
cDC | conventional dendritic cells; |
CRAMP | cathelicidin related antimicrobial peptide; |
EFGR | epidermal growth factor receptor; |
FPRL-1 | formyl peptide receptor-like 1; |
GPCR | G-protein coupled receptor; |
IFN | interferon; |
LPS | lipopolysaccharides; |
NK cells | natural killer cells; |
pDC | plasmacytoid dendritic cells; |
PE | phosphatidylethanolamine; |
PG | phosphatidylglycerol; |
PS | phosphatidylserine; |
TLR | toll-like receptor. |
Acknowledgements
References
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Seil, M.; Nagant, C.; Dehaye, J.-P.; Vandenbranden, M.; Lensink, M.F. Spotlight on Human LL-37, an Immunomodulatory Peptide with Promising Cell-Penetrating Properties. Pharmaceuticals 2010, 3, 3435-3460. https://doi.org/10.3390/ph3113435
Seil M, Nagant C, Dehaye J-P, Vandenbranden M, Lensink MF. Spotlight on Human LL-37, an Immunomodulatory Peptide with Promising Cell-Penetrating Properties. Pharmaceuticals. 2010; 3(11):3435-3460. https://doi.org/10.3390/ph3113435
Chicago/Turabian StyleSeil, Michèle, Carole Nagant, Jean-Paul Dehaye, Michel Vandenbranden, and Marc Ferdinand Lensink. 2010. "Spotlight on Human LL-37, an Immunomodulatory Peptide with Promising Cell-Penetrating Properties" Pharmaceuticals 3, no. 11: 3435-3460. https://doi.org/10.3390/ph3113435
APA StyleSeil, M., Nagant, C., Dehaye, J. -P., Vandenbranden, M., & Lensink, M. F. (2010). Spotlight on Human LL-37, an Immunomodulatory Peptide with Promising Cell-Penetrating Properties. Pharmaceuticals, 3(11), 3435-3460. https://doi.org/10.3390/ph3113435