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Volume 25
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10.21775/cimb.025.169
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Current Issues in Molecular Biology is published by MDPI from Volume 43 Issue 1 (2021). Previous articles were published by another publisher in Open Access under a CC-BY (or CC-BY-NC-ND) licence, and they are hosted by MDPI on mdpi.com as a courtesy and upon agreement with Caister Press.
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Review

Immune-Evasion Strategies of Mycobacteria and Their Implications for the Protective Immune Response

by
Alexandra G. Fraga
1,2,
Ana Margarida Barbosa
1,2,
Catarina M. Ferreira
1,2,
João Fevereiro
1,2,
Jorge Pedrosa
1,2 and
Egídio Torrado
1,2,*
1
1Life and Health Sciences Research Institute (ICVS), School of Medicine, University of Minho, Braga, Portugal
2
PT Government Associate Laboratory ICVS/3B’s , University of Minho, Braga, Portugal
*
Author to whom correspondence should be addressed.
Curr. Issues Mol. Biol. 2018, 25(1), 169-198; https://doi.org/10.21775/cimb.025.169
Submission received: 7 June 2017 / Revised: 2 July 2017 / Accepted: 3 August 2017 / Published: 6 September 2017

Abstract

Mycobacteria are intracellular pathogens that have macrophages as their main host cells. However, macrophages are also the primary line of defence against invading microorganisms. To survive in the intracellular compartment, virulent mycobacteria have developed several strategies to modulate the activation and the effector functions of macrophages. Despite this, antigen-specific T cells develop during infection. While T-cell responses are critical for protection they can also contribute to the success of mycobacteria as human pathogens, as immunopathology associated with these responses facilitates transmission. Here, we provide a brief overview of different immune-evasion strategies of mycobacteria and their impact on the protective immune response. This understanding will further our knowledge on host–pathogen interactions and may provide critical insights for the development of novel host-specific therapies.
Keywords: immune-evasion; strategies; mycobacteria; their; implications; protective; immune; response immune-evasion; strategies; mycobacteria; their; implications; protective; immune; response

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MDPI and ACS Style

Fraga, A.G.; Barbosa, A.M.; Ferreira, C.M.; Fevereiro, J.; Pedrosa, J.; Torrado, E. Immune-Evasion Strategies of Mycobacteria and Their Implications for the Protective Immune Response. Curr. Issues Mol. Biol. 2018, 25, 169-198. https://doi.org/10.21775/cimb.025.169

AMA Style

Fraga AG, Barbosa AM, Ferreira CM, Fevereiro J, Pedrosa J, Torrado E. Immune-Evasion Strategies of Mycobacteria and Their Implications for the Protective Immune Response. Current Issues in Molecular Biology. 2018; 25(1):169-198. https://doi.org/10.21775/cimb.025.169

Chicago/Turabian Style

Fraga, Alexandra G., Ana Margarida Barbosa, Catarina M. Ferreira, João Fevereiro, Jorge Pedrosa, and Egídio Torrado. 2018. "Immune-Evasion Strategies of Mycobacteria and Their Implications for the Protective Immune Response" Current Issues in Molecular Biology 25, no. 1: 169-198. https://doi.org/10.21775/cimb.025.169

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