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Current Issues in Molecular Biology is published by MDPI from Volume 43 Issue 1 (2021). Previous articles were published by another publisher in Open Access under a CC-BY (or CC-BY-NC-ND) licence, and they are hosted by MDPI on mdpi.com as a courtesy and upon agreement with Caister Press.
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Review

CRISPR-Cas Systems in Streptococci

by
Tao Gong
†,
Miao Lu
†,
Xuedong Zhou
,
Anqi Zhang
,
Boyu Tang
,
Jiamin Chen
,
Meiling Jing
and
Yuqing Li
*
State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, China
*
Author to whom correspondence should be addressed.
†
These authors are contributed equally to this work.
Curr. Issues Mol. Biol. 2019, 32(1), 1-38; https://doi.org/10.21775/cimb.032.001
Submission received: 13 March 2019 / Revised: 10 April 2019 / Accepted: 11 May 2019 / Published: 5 June 2019
Versions Notes

Abstract

Streptococci are one of the most important and common constituents of the host's microbiota and can colonize and live in the upper respiratory and urogenital tract of humans and animals. The CRISPR-Cas systems (i.e., clustered regularly interspaced short palindromic repeat, with CRISPR-associated proteins) found in bacteria and archaea provide sequence-based adaptive immunity against mobile genetic elements, especially in the streptococci. Here, recent research progress on CRISPR-Cas systems in the streptococci is reviewed, including their classification (mainly type I, type II, and type III), physiological function, defense mechanism (CRISPR adaptation, crRNA biogenesis, and target interference) and applications, which are useful for a better understanding of the functions of such systems. Finally, the advances that have been made in streptococci may help in the discovery of further novel CRISPR-Cas systems for use in new technologies and applications in other species.
Keywords: CRISPR-Cas; systems; streptococci CRISPR-Cas; systems; streptococci

Share and Cite

MDPI and ACS Style

Gong, T.; Lu, M.; Zhou, X.; Zhang, A.; Tang, B.; Chen, J.; Jing, M.; Li, Y. CRISPR-Cas Systems in Streptococci. Curr. Issues Mol. Biol. 2019, 32, 1-38. https://doi.org/10.21775/cimb.032.001

AMA Style

Gong T, Lu M, Zhou X, Zhang A, Tang B, Chen J, Jing M, Li Y. CRISPR-Cas Systems in Streptococci. Current Issues in Molecular Biology. 2019; 32(1):1-38. https://doi.org/10.21775/cimb.032.001

Chicago/Turabian Style

Gong, Tao, Miao Lu, Xuedong Zhou, Anqi Zhang, Boyu Tang, Jiamin Chen, Meiling Jing, and Yuqing Li. 2019. "CRISPR-Cas Systems in Streptococci" Current Issues in Molecular Biology 32, no. 1: 1-38. https://doi.org/10.21775/cimb.032.001

APA Style

Gong, T., Lu, M., Zhou, X., Zhang, A., Tang, B., Chen, J., Jing, M., & Li, Y. (2019). CRISPR-Cas Systems in Streptococci. Current Issues in Molecular Biology, 32(1), 1-38. https://doi.org/10.21775/cimb.032.001

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