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Current Issues in Molecular Biology is published by MDPI from Volume 43 Issue 1 (2021). Previous articles were published by another publisher in Open Access under a CC-BY (or CC-BY-NC-ND) licence, and they are hosted by MDPI on mdpi.com as a courtesy and upon agreement with Caister Press.
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Review

Stealth Strategies of Mycobacterium tuberculosis for Immune Evasion

by
Muhammad Ahsan Naeem
1,
Waqas Ahmad
1,
Rohit Tyagi
2,
Qaiser Akram
1,
Muhammad Younus
1 and
Xilin Liu
3,*
1
University College of Veterinary and Animal Sciences, Narowal 51600, Pakistan
2
College of Veterinary Medicine, Huazhong Agricultural University, Wuhan 430070, China
3
Department of Hand Surgery, China Japan Union Hospital, Jilin University, 126 XianTai Street, Changchun, China
*
Author to whom correspondence should be addressed.
Curr. Issues Mol. Biol. 2021, 41(1), 597-616; https://doi.org/10.21775/cimb.041.597
Submission received: 3 July 2020 / Revised: 5 August 2020 / Accepted: 9 September 2020 / Published: 17 October 2020
Versions Notes

Abstract

Tuberculosis is a devastating disease causing high mortality all over the world, especially in the developing countries. Mycobacterium tuberculosis (M. tb) is the causative agent of tuberculosis which replicates in the intracellular environment of host macrophages. Although the host immune system is capable of completely eliminating the pathogen, co-evolution of M. tb with humans has resulted in its ability to hijack the host innate and adaptive immune systems in numerous ways. Limited recent progress has been made in the understanding of M. tb immune escape mechanisms, hence exploration of survival strategies of M. tb has been critically reviewed with an insight into understanding its pathogenesis. We summarized the recent studies regarding the modulation of innate immune response, adaptive immune response, epigenetics and the role of miRNA. All of these advancements suggest that M. tb is well-familiarize with the host immune system and possess the ability to hijack it for intracellular survival.
Keywords: Tuberculosis; Innate Immunity; Bacterial Factors; Adaptive Immunity; Survival Tuberculosis; Innate Immunity; Bacterial Factors; Adaptive Immunity; Survival

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MDPI and ACS Style

Naeem, M.A.; Ahmad, W.; Tyagi, R.; Akram, Q.; Younus, M.; Liu, X. Stealth Strategies of Mycobacterium tuberculosis for Immune Evasion. Curr. Issues Mol. Biol. 2021, 41, 597-616. https://doi.org/10.21775/cimb.041.597

AMA Style

Naeem MA, Ahmad W, Tyagi R, Akram Q, Younus M, Liu X. Stealth Strategies of Mycobacterium tuberculosis for Immune Evasion. Current Issues in Molecular Biology. 2021; 41(1):597-616. https://doi.org/10.21775/cimb.041.597

Chicago/Turabian Style

Naeem, Muhammad Ahsan, Waqas Ahmad, Rohit Tyagi, Qaiser Akram, Muhammad Younus, and Xilin Liu. 2021. "Stealth Strategies of Mycobacterium tuberculosis for Immune Evasion" Current Issues in Molecular Biology 41, no. 1: 597-616. https://doi.org/10.21775/cimb.041.597

APA Style

Naeem, M. A., Ahmad, W., Tyagi, R., Akram, Q., Younus, M., & Liu, X. (2021). Stealth Strategies of Mycobacterium tuberculosis for Immune Evasion. Current Issues in Molecular Biology, 41(1), 597-616. https://doi.org/10.21775/cimb.041.597

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