Implications of Concurrent IDH1 and IDH2 Mutations on Survival in Glioma—A Case Report and Systematic Review
Abstract
:1. Introduction
2. Materials and Methods
2.1. Genomic Database Interrogation
2.2. Data Sources and Search Strategy
- Pubmed (from 1966)
- Ovid MEDLINE (from 1950)
- Ovid Embase (from 1974)
2.3. Selection Criteria and Process
2.4. Data Extraction
3. Results
3.1. Case Presentation
3.2. Genomic Database Interrogation Did Not Yield a Co-occurring IDH1 and IDH2 Mutation in Glioma Datasets
3.3. Systematic Review of the Literature Shows Rare Co-occurring IDH1 and IDH2 SNVs in Cancer
3.3.1. Acute Myeloid Leukaemia
3.3.2. Chondrosarcoma
3.3.3. Glioma
4. Discussion
5. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Conflicts of Interest
References
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Study | Malignancy Type | Proportion with IDH1/2 Co-Mutation | Method of Genomic Testing | Associated Mutations | Clinical Outcomes |
---|---|---|---|---|---|
Meggendorfer et al. [28] | AML | 7/1394 (0.5%) | NGS | Not reported | Not reported |
Platt et al. [27] | AML | 3/53 (5.7%) | NGS | FLT3 | 1 patient remains alive and well 24 months post allogeneic transplant, 1 patient surviving for 14 months post diagnosis and 1 patient surviving three months post diagnosis |
CEBPA | |||||
NPM1 | |||||
Petrova et al. [29] | AML | 1/90 (1.1%) | NGS | Not reported | Not reported |
Nayak et al. [26] | AML | 1/33 (3.0%) | Sanger | Not reported | Not reported |
sequencing | |||||
Lugowska et al. [30] | CS | 3/80 (3.8%) | NGS | Not reported | Not reported |
Hartman et al. [31] | A | 1/228 (0.4%) | NGS | Not reported | Not reported |
O | 1/174 (0.6%) | ||||
OA | 2/177 (1.1%) |
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Yuile, A.; Satgunaseelan, L.; Wei, J.; Kastelan, M.; Back, M.F.; Lee, M.; Wei, H.; Buckland, M.E.; Lee, A.; Wheeler, H.R. Implications of Concurrent IDH1 and IDH2 Mutations on Survival in Glioma—A Case Report and Systematic Review. Curr. Issues Mol. Biol. 2022, 44, 5117-5125. https://doi.org/10.3390/cimb44100348
Yuile A, Satgunaseelan L, Wei J, Kastelan M, Back MF, Lee M, Wei H, Buckland ME, Lee A, Wheeler HR. Implications of Concurrent IDH1 and IDH2 Mutations on Survival in Glioma—A Case Report and Systematic Review. Current Issues in Molecular Biology. 2022; 44(10):5117-5125. https://doi.org/10.3390/cimb44100348
Chicago/Turabian StyleYuile, Alexander, Laveniya Satgunaseelan, Joe Wei, Marina Kastelan, Michael F. Back, Maggie Lee, Heng Wei, Michael E. Buckland, Adrian Lee, and Helen R. Wheeler. 2022. "Implications of Concurrent IDH1 and IDH2 Mutations on Survival in Glioma—A Case Report and Systematic Review" Current Issues in Molecular Biology 44, no. 10: 5117-5125. https://doi.org/10.3390/cimb44100348
APA StyleYuile, A., Satgunaseelan, L., Wei, J., Kastelan, M., Back, M. F., Lee, M., Wei, H., Buckland, M. E., Lee, A., & Wheeler, H. R. (2022). Implications of Concurrent IDH1 and IDH2 Mutations on Survival in Glioma—A Case Report and Systematic Review. Current Issues in Molecular Biology, 44(10), 5117-5125. https://doi.org/10.3390/cimb44100348