LSD1 for the Targeted Regulation of Adipose Tissue

Round 1

Reviewer 1 Report

The current review summarizes the available data concerning the activity of LSD1 in regulating the thermogenic gene program of brown and beige adipose tissue. The review describes the main reported pathways which LSD1 acts through, and it is a good attempt to summarize the current knowledge about this field. However, some aspects of the manuscript need to be improved before publication.

-          Manuscript must be revised by an English-style professional. The readability and comprehension of the text is very low. Moreover, the text has numerous spelling and punctuation mistakes.

-          In section 4 (l. 217), authors introduce some results as own results (“we have demonstrated…”), but none of the references 70-72 is authored by the authors. Similarly, in other sections, there are some expressions that may lead the reader to the same conclusion.

-          In section 4.6 (l. 355), “a large number of studies…” is not accompanied by any reference.

-          The relevance of figure 1 is scarce. It would be more useful for the comprehension of the review, to include some figures/graphical abstracts depicting the main/more complex molecular mechanisms where LSD1 plays a role regulating browning.

Author Response

Response to Reviewer 1 Comments

 

Point 1:  Manuscript must be revised by an English-style professional. The readability and comprehension of the text is very low. Moreover, the text has numerous spelling and punctuation mistakes. 

 

Response 1: Thank you very much for your modification suggestions. I highlight the additions in yellow and the deletions in red or blue.In order to correct the mistakes in grammar, as a human readable articles, we have English polishing service for your paper at https://www.mdpi.com/authors/english.

Point 2:  In section 4 (l. 217), authors introduce some results as own results (“we have demonstrated…”), but none of the references 70-72 is authored by the authors. Similarly, in other sections, there are some expressions that may lead the reader to the same conclusion.

Response 2: Sorry for our lapse in logic.In section 4 (l.),we removed (" we have demonstrated... ), and ("it has been recently found... ") substitute. Everywhere else, we try to speculate after summarizing the results of others, rather than we directly draw the results.

Point 3:   In section 4.6 (l. 355), “a large number of studies…” is not accompanied by any reference.

Response 3: We agree with this opinion and have added the corresponding references.

Point 4:   The relevance of figure 1 is scarce. It would be more useful for the comprehension of the review, to include some figures/graphical abstracts depicting the main/more complex molecular mechanisms where LSD1 plays a role regulating browning.

Response 4: Thank you very much for your comments on the modification of Figure 1. Figure 1 is mainly used to describe the cell morphological differences of three kinds of adipose tissues. After modification, we can more intuitively reflect the molecular effects of LSD1 on adipose tissue cells.

Please see the attachment.

Author Response File: Author Response.docx

Reviewer 2 Report

Comments to Authors 

 

            This study showed that LSD1 is indeed an important target for regulating the transformation of adipose tissue, and LSD1 can indeed become an important target for the treatment of obesity-related metabolic diseases, providing some new ideas for improving the pathophysiological state related to adipose tissue transformation, such as diabetes and atherosclerosis.

          Authors are kindly requested to emphasize the current concepts about these issues in the context of recent knowledge and the available literature. This articles should be quoted in the References list.

References

11.      MiR-137 knockdown promotes the osteogenic differentiation of human adipose-derived stem cells via the LSD1/BMP2/SMAD4 signaling network. J Cell Physiol. 2020; 235 (2): 909-919. doi:10.1002/jcp.29006.

22.      Lysine-Specific Demethylase 1 in Energy Metabolism: A Novel Target for Obesity. J Nutr. 2022; 152 (7): 1611-1620. doi:10.1093/jn/nxac080.

33.     Systemic LSD1 Inhibition Prevents Aberrant Remodeling of Metabolism in Obesity [published online ahead of print, 2022 Sep 26]. Diabetes. 2022; db211131. doi:10.2337/db21-1131.

Author Response

Response to Reviewer 2 Comments

 

Point 1:  This study showed that LSD1 is indeed an important target for regulating the transformation of adipose tissue, and LSD1 can indeed become an important target for the treatment of obesity-related metabolic diseases, providing some new ideas for improving the pathophysiological state related to adipose tissue transformation, such as diabetes and atherosclerosis.

 

          Authors are kindly requested to emphasize the current concepts about these issues in the context of recent knowledge and the available literature. This articles should be quoted in the References list.

 

References

 

11.      MiR-137 knockdown promotes the osteogenic differentiation of human adipose-derived stem cells via the LSD1/BMP2/SMAD4 signaling network. J Cell Physiol. 2020; 235 (2): 909-919. doi:10.1002/jcp.29006.

 

22.      Lysine-Specific Demethylase 1 in Energy Metabolism: A Novel Target for Obesity. J Nutr. 2022; 152 (7): 1611-1620. doi:10.1093/jn/nxac080.

 

33.     Systemic LSD1 Inhibition Prevents Aberrant Remodeling of Metabolism in Obesity [published online ahead of print, 2022 Sep 26]. Diabetes. 2022; db211131. doi:10.2337/db21-1131.

Response 1: Thank you very much for your modification suggestions. I highlight the additions in yellow and the deletions in red or blue.We have read these references, inserted them into the corresponding parts of the article according to the content, and made corresponding modifications to the article.

 

 

Author Response File: Author Response.docx

Round 2

Reviewer 1 Report

The authors have addressed the suggestions from the first review