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Review

Oxytocin, the Love Hormone, in Stem Cell Differentiation

by
Luca Pampanella
1,
Giovannamaria Petrocelli
1,
Federica Forcellini
1,
Sara Cruciani
2,
Carlo Ventura
1,3,
Provvidenza Maria Abruzzo
1,*,
Federica Facchin
1,4,* and
Silvia Canaider
1,4
1
Department of Medical and Surgical Sciences (DIMEC), University of Bologna, Via Massarenti 9, 40138 Bologna, Italy
2
Department of Biomedical Sciences, University of Sassari, Viale San Pietro 43/B, 07100 Sassari, Italy
3
National Laboratory of Molecular Biology and Stem Cell Bioengineering, National Institute of Biostructures and Biosystems (NIBB), Via di Corticella 183, 40129 Bologna, Italy
4
IRCCS Azienda Ospedaliero-Universitaria di Bologna, Via Massarenti 9, 40138 Bologna, Italy
*
Authors to whom correspondence should be addressed.
Curr. Issues Mol. Biol. 2024, 46(11), 12012-12036; https://doi.org/10.3390/cimb46110713
Submission received: 28 August 2024 / Revised: 23 October 2024 / Accepted: 23 October 2024 / Published: 25 October 2024
(This article belongs to the Special Issue Current Advances in Oxytocin Research)
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Abstract

Oxytocin (OXT) is a neurohypophysial nonapeptide that exerts its effects mainly through the oxytocin receptor (OXTR). Several studies have pointed out the role of OXT in the modulation of stem cell (SC) fate and properties. SCs are undifferentiated cells characterized by a remarkable ability to self-renew and differentiate into various cell types of the body. In this review, we focused on the role of OXT in SC differentiation. Specifically, we summarize and discuss the scientific research examining the effects of OXT on mesodermal SC-derived lineages, including cardiac, myogenic, adipogenic, osteogenic, and chondrogenic differentiation. The available studies related to the effects of OXT on SC differentiation provide little insights about the molecular mechanism mediated by the OXT–OXTR pathway. Further research is needed to fully elucidate these pathways to effectively modulate SC differentiation and develop potential therapeutic applications in regenerative medicine.
Keywords: oxytocin; oxytocin receptor; stem cells; stem cell differentiation; cardiogenesis; myogenesis; adipogenesis; osteogenesis; chondrogenesis; odontogenesis oxytocin; oxytocin receptor; stem cells; stem cell differentiation; cardiogenesis; myogenesis; adipogenesis; osteogenesis; chondrogenesis; odontogenesis
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MDPI and ACS Style

Pampanella, L.; Petrocelli, G.; Forcellini, F.; Cruciani, S.; Ventura, C.; Abruzzo, P.M.; Facchin, F.; Canaider, S. Oxytocin, the Love Hormone, in Stem Cell Differentiation. Curr. Issues Mol. Biol. 2024, 46, 12012-12036. https://doi.org/10.3390/cimb46110713

AMA Style

Pampanella L, Petrocelli G, Forcellini F, Cruciani S, Ventura C, Abruzzo PM, Facchin F, Canaider S. Oxytocin, the Love Hormone, in Stem Cell Differentiation. Current Issues in Molecular Biology. 2024; 46(11):12012-12036. https://doi.org/10.3390/cimb46110713

Chicago/Turabian Style

Pampanella, Luca, Giovannamaria Petrocelli, Federica Forcellini, Sara Cruciani, Carlo Ventura, Provvidenza Maria Abruzzo, Federica Facchin, and Silvia Canaider. 2024. "Oxytocin, the Love Hormone, in Stem Cell Differentiation" Current Issues in Molecular Biology 46, no. 11: 12012-12036. https://doi.org/10.3390/cimb46110713

APA Style

Pampanella, L., Petrocelli, G., Forcellini, F., Cruciani, S., Ventura, C., Abruzzo, P. M., Facchin, F., & Canaider, S. (2024). Oxytocin, the Love Hormone, in Stem Cell Differentiation. Current Issues in Molecular Biology, 46(11), 12012-12036. https://doi.org/10.3390/cimb46110713

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