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Article

Frankincense (Boswellia serrata) Extract Effects on Growth and Biofilm Formation of Porphyromonas gingivalis, and Its Intracellular Infection in Human Gingival Epithelial Cells

by
David Vang
1,
Aline Cristina Abreu Moreira-Souza
1,
Nicholas Zusman
2,
German Moncada
1,
Harmony Matshik Dakafay
1,
Homer Asadi
1,
David M. Ojcius
1 and
Cassio Luiz Coutinho Almeida-da-Silva
1,*
1
Department of Biomedical Sciences, Arthur A. Dugoni School of Dentistry, University of the Pacific, San Francisco, CA 94103, USA
2
Dental Surgery Program, Arthur A. Dugoni School of Dentistry, University of the Pacific, San Francisco, CA 94103, USA
*
Author to whom correspondence should be addressed.
Curr. Issues Mol. Biol. 2024, 46(4), 2991-3004; https://doi.org/10.3390/cimb46040187
Submission received: 1 February 2024 / Revised: 20 March 2024 / Accepted: 28 March 2024 / Published: 30 March 2024
(This article belongs to the Special Issue Frankincense (Heaven’s Gift)—Chemical and Biological Diversity)
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Abstract

Frankincense is produced by Boswellia trees, which can be found throughout the Middle East and parts of Africa and Asia. Boswellia serrata extract has been shown to have anti-cancer, anti-inflammatory, and antimicrobial effects. Periodontitis is an oral chronic inflammatory disease that affects nearly half of the US population. We investigated the antimicrobial effects of B. serrata extract on two oral pathogens associated with periodontitis. Using the minimum inhibitory concentration and crystal violet staining methods, we demonstrated that Porphyromonas gingivalis growth and biofilm formation were impaired by treatment with B. serrata extracts. However, the effects on Fusobacterium nucleatum growth and biofilm formation were not significant. Using quantification of colony-forming units and microscopy techniques, we also showed that concentrations of B. serrata that were not toxic for host cells decreased intracellular P. gingivalis infection in human gingival epithelial cells. Our results show antimicrobial activity of a natural product extracted from Boswellia trees (B. serrata) against periodontopathogens. Thus, B. serrata has the potential for preventing and/or treating periodontal diseases. Future studies will identify the molecular components of B. serrata extracts responsible for the beneficial effects.
Keywords: Porphyromonas gingivalis; Fusobacterium nucleatum; Boswellia serrata; biofilm; epithelial cells Porphyromonas gingivalis; Fusobacterium nucleatum; Boswellia serrata; biofilm; epithelial cells

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MDPI and ACS Style

Vang, D.; Moreira-Souza, A.C.A.; Zusman, N.; Moncada, G.; Matshik Dakafay, H.; Asadi, H.; Ojcius, D.M.; Almeida-da-Silva, C.L.C. Frankincense (Boswellia serrata) Extract Effects on Growth and Biofilm Formation of Porphyromonas gingivalis, and Its Intracellular Infection in Human Gingival Epithelial Cells. Curr. Issues Mol. Biol. 2024, 46, 2991-3004. https://doi.org/10.3390/cimb46040187

AMA Style

Vang D, Moreira-Souza ACA, Zusman N, Moncada G, Matshik Dakafay H, Asadi H, Ojcius DM, Almeida-da-Silva CLC. Frankincense (Boswellia serrata) Extract Effects on Growth and Biofilm Formation of Porphyromonas gingivalis, and Its Intracellular Infection in Human Gingival Epithelial Cells. Current Issues in Molecular Biology. 2024; 46(4):2991-3004. https://doi.org/10.3390/cimb46040187

Chicago/Turabian Style

Vang, David, Aline Cristina Abreu Moreira-Souza, Nicholas Zusman, German Moncada, Harmony Matshik Dakafay, Homer Asadi, David M. Ojcius, and Cassio Luiz Coutinho Almeida-da-Silva. 2024. "Frankincense (Boswellia serrata) Extract Effects on Growth and Biofilm Formation of Porphyromonas gingivalis, and Its Intracellular Infection in Human Gingival Epithelial Cells" Current Issues in Molecular Biology 46, no. 4: 2991-3004. https://doi.org/10.3390/cimb46040187

APA Style

Vang, D., Moreira-Souza, A. C. A., Zusman, N., Moncada, G., Matshik Dakafay, H., Asadi, H., Ojcius, D. M., & Almeida-da-Silva, C. L. C. (2024). Frankincense (Boswellia serrata) Extract Effects on Growth and Biofilm Formation of Porphyromonas gingivalis, and Its Intracellular Infection in Human Gingival Epithelial Cells. Current Issues in Molecular Biology, 46(4), 2991-3004. https://doi.org/10.3390/cimb46040187

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