MicroRNAs as Regulators of Radiation-Induced Oxidative Stress
Abstract
:1. Introduction
2. Radiation and Oxidative Stress
3. MiRNAs Affect ROS Production and Elimination
4. Evidence for miRNA Action in Radiation-Induced Oxidative Stress
4.1. Nrf2 Pathway
4.2. NF-κB Pathway
4.3. p53 Pathway
4.4. FOXO Pathway
4.5. SIRT Pathway
4.6. MAPK Pathway
5. miRNAs as Potential Therapeutics
6. Conclusions
Author Contributions
Funding
Conflicts of Interest
Abbreviations
4-HNE | 4-hydroxy-2-nonenal |
8-OHdG | 8-hydroxy-2′-deoxyguanosine |
AKT | protein kinase B |
AMPK | adenosine monophosphate-activated protein kinase |
AP-1 | activator protein 1 |
AP2a | activator protein 2a |
Bcl-2 | B-cell lymphoma 2 |
CAT | catalase |
COX | cyclooxygenase |
DSB | double-strand break |
eNOS | endothelial nitric oxide synthase |
ERK | extracellular-signal-regulated kinase |
FOXO | Forkhead box O |
GPx | glutathione peroxidase |
GR | glutathione reductase |
HIF-1α | hypoxia-inducible factor 1 alpha |
HLEC | human lens epithelial cell |
HO | heme oxygenase |
H2O2 | hydrogen peroxide |
HUVEC | human umbilical vein cell |
IκBα | inhibitory protein alpha of nuclear factor kappa B |
JNK | c-Jun N-terminal kinase |
Keap 1 | Kelch-like ECH-associated protein 1 |
LDH | lactate dehydrogenase |
LOX | lipoxygenase |
MAPK | mitogen-activated protein kinase |
MDA | malondialdehyde |
mRNA | messenger RNA |
miRNA | microRNA |
NF-κB | nuclear factor kappa B |
NOS | nitric oxide synthase |
NOX | NADPH oxidase |
Nrf2 | nuclear factor erythroid 2-related factor 2 |
O2•− | superoxide anion |
•OH | hydroxyl radical |
p53 | tumor suppressor protein p53 |
PRDX | peroxiredoxin |
pre-miRNA | precursor form of microRNA |
pri-miRNA | primary nuclear transcript of microRNA |
Redd1 | regulated in development and DNA damage responses 1 |
RGC | retinal ganglion cell |
RISC | RNA-induced silencing complex |
RNS | reactive nitrogen species |
ROS | reactive oxygen species |
RPE | retinal pigment epithelium cells |
SIRT | sirtuin |
SOD | superoxide dismutase |
SPRY-2 | sprouty homolog 2 |
SSB | single-strand break |
STAT3 | signal transducer and activator of transcription 3 |
TXN | thioredoxin |
TXNRD | thioredoxin reductase |
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miRNA | ROS-Producing Enzyme | Experimental Model | Reference |
---|---|---|---|
miRNA-124-5p | NOX2 | rats cerebral I/R injury | [42] |
miRNA-34a | NOX2 | human glioma cells | [43] |
miRNA-320 | NOX2 | ischemic cerebral neurons | [44] |
miRNA-423-5p | NOX4 | mouse podocyte cells | [45] |
miRNA-99a | NOX4 | lung adenocarcinoma cells | [46] |
miRNA-182-5p | NOX4 | human lens epithelial cells | [47] |
miRNA-200c | eNOS | HUVEC cells | [48] |
miRNA-615-5p | eNOS | HUVEC cells | [49] |
miRNA-155 | eNOS | HUVEC cells | [50] |
miRNA | Antioxidant Enzyme | Experimental Model | Reference |
---|---|---|---|
miRNA-21 | SOD | human bronchial epithelial cells | [52] |
miRNA-17-3p | SOD, GPx, TXNRD | prostate cancer cells | [53] |
miRNA-23a | SOD | cardiomyocytes | [54] |
miRNA-30b | CAT | human retinal pigment epithelial cell line | [55] |
miRNA-551b | CAT | human lung cancer cells | [56] |
miRNA-144 | GPx, GR | human neuroblastoma SH-SY5Y cells | [57] |
miRNA-181a | GPx | cardiomyocytes | [58] |
miRNA-214 | GR | liver cells | [59] |
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Kura, B.; Pavelkova, P.; Kalocayova, B.; Pobijakova, M.; Slezak, J. MicroRNAs as Regulators of Radiation-Induced Oxidative Stress. Curr. Issues Mol. Biol. 2024, 46, 7097-7113. https://doi.org/10.3390/cimb46070423
Kura B, Pavelkova P, Kalocayova B, Pobijakova M, Slezak J. MicroRNAs as Regulators of Radiation-Induced Oxidative Stress. Current Issues in Molecular Biology. 2024; 46(7):7097-7113. https://doi.org/10.3390/cimb46070423
Chicago/Turabian StyleKura, Branislav, Patricia Pavelkova, Barbora Kalocayova, Margita Pobijakova, and Jan Slezak. 2024. "MicroRNAs as Regulators of Radiation-Induced Oxidative Stress" Current Issues in Molecular Biology 46, no. 7: 7097-7113. https://doi.org/10.3390/cimb46070423