Review on Long Non-Coding RNAs as Biomarkers and Potentially Therapeutic Targets for Bacterial Infections
Abstract
:1. Introduction
2. Biogenesis, Location, and Molecular Regulation of lncRNAs
3. LncRNAs as Biomarkers for the Occurrence and Development of Bacterial Invasion
4. LncRNAs as Probable Therapeutic Targets for Bacterial Infections
4.1. Targeted Regulation of Pathogenicity by lncRNAs in Bacterial Infections
4.2. Targeted Regulation in Cell Lesions Induced by Bacterial Stimulation
4.3. Targeted Mediation of lncRNAs Inflammation Process Induced by Bacterial Infections
4.4. Targeted Modulation of lncRNAs in the Immune System of the Antibacterial Parade
Pathogen | LncRNA | Regulation | Target Cells | Mechanisms | References |
---|---|---|---|---|---|
S. aureus | SSR42 | Up | Encoded by bacteria | Involves in S. aureus hemolysis induced by antibiotics | [50] |
LINC00847 | Up | Renal cancer cells | Arrests cell cycle and results in activation of apoptosis through regulatory lncRNA and tst gene | [89] | |
RNAIII | Up | Encoded by bacteria | Regulates staphylococcal alpha-toxin at the translational level through base pairing with HLA mRNA | [90] | |
lnc-AFTR | Down | S. aureus-induced MAC-T cells and mastitis tissues | Inhibits apoptosis and inflammation by blocking FAS mRNA translation | [91] | |
L. monocytogenes | SROS1 | Down | Macrophage | Degraded by upregulated miR-1 to release RBP CAPRIN1, thus improving the stabilization of Stat1 mRNA | [71] |
lincRNA-EPS | Down | Macrophage | Interacts with hnRNPL to repress immune-responsive gene-1 expression | [72] | |
lincRNA-Cox2 | Up | Macrophage | Regulates the assembly of NF-κB subunits to the SWI/SNF complex, thereby promoting late inflammatory gene transcription | [92,110] | |
Morrbid | Up | Eosinophils, Macrophage | Controls apoptosis of highly inflammatory cells such as eosinophils by regulating the expression of the pro-apoptotic factor Bcl2l11 | [107] | |
AS-IL1α | Up | Macrophage | RNA polymerase II recruitment to the IL-1α promotor | [79] | |
Mtb | lncRNA CD244 | Up | CD8+ T-cells | Recruits Ezh2 to mediate the trimethylation of H3K27 in IFN-γ/TNF-α locus | [68] |
NEAT1 | Up | Monocyte, Macrophage | Regulates IL-6 expression | [69] | |
PCED1B-AS1 | Down | Macrophage | As a miR-155 sponge, inhibiting macrophage apoptosis by regulating FOXO3/Rheb | [94] | |
lincRNA-Cox2 | Up | Macrophage | Regulates the inflammatory response of TB infection macrophages through Stat3 and NF-κB signaling pathways | [97] | |
HOTAIR | Up (H37Ra-infected) Down (H37Rv-infected) | Macrophage | Likely regulates the expression of DUSP4 and SATB1 by recruiting EZH2 during infection | [111] | |
Salmonella | NEAT1 | Up | HeLa cells | Alters expression of host immune genes | [61] |
IFNG-AS1 | Up | Macrophages and murine tissues | Interacts with WDR5 to promote histone methylation at the IFN-γ locus | [82] | |
M. smegmatis | MEG3 | Up | Macrophage | Inhibits the expression of TGF-β by forming RNA-DNA triplex structures | [70] |
M. bovis BCG | MEG3 | Down | Macrophage | IFN-γ-induced autophagy | [81] |
Pulmonary tuberculosis; M. bovis BCG | lincRNA-EPS | Down | Monocyte, Macrophage | Regulation of apoptosis and autophagy | [80] |
E. coli or S. aureus | lncRNA-TUB | Up | MAC-T cells | Regulates the morphology, proliferation, migration, and β-casein secretion of mammary epithelial cells | [39] |
lncRNA-XIST | Up | MAC-T cells | Inhibits E. coli or S. aureus-induced NF-κB phosphorylation and the production of NLRP3 inflammasome | [95] | |
E. coli | lncRNA-Mirt2 | Up | Macrophage | Inhibits the K63-ubiquitination of TRAF6 and thus alleviates inflammatory responses after TLR4 activation and balances macrophage polarization | [96] |
LPS stimulation | lincRNA-Tnfaip3 | Up | Macrophage | Acts as a coactivator of NF-κB for the transcription of inflammatory genes through modulation of epigenetic chromatin remodeling | [98] |
lncRNA-MRF | Up | Monocyte | Increases monocyte recruitment by upregulating the expression of monocyte chemotactic protein | [103] | |
H. pylori | lnc-SGK1 | Up | T cells in human gastric cancer | Enhances SGK1 transcription in cis to induce TH2 and TH17 differentiation and inhibit TH1 differentiation | [52] |
lnc-GNAT1 | Down | Gastric cancer cells | Impedes cancer cell migration through Wnt/β-catenin pathway protein expression inhibition | [53] | |
ZFAS1 | Up | Colorectal cancer tissues | Interacts with CDK1 to be involved in p53-dependent cell cycle control and apoptosis | [77] | |
P. aeruginosa | MEG3-4 | Down | Macrophage, Epithelial cells | Bindings to miRNA-138, thereby releasing interleukin-1β to augment inflammatory responses | [112] |
4.5. Could lncRNAs Be Targeted as a Promising Solution to the Current Antibiotic Resistance?
5. Conclusions and Future Outlook
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
References
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Pathogen | LncRNA | Expression | Role | References |
---|---|---|---|---|
Brucella spp. | Gm28309 | Down | Shows potential as a biomarker in the disease progression for brucellosis | [64] |
IFNG-AS1 | Up | Enhances the expression of INF-γ in the immune response of brucellosis patients, revealing its potential in screening, diagnosis, or treatment of brucellosis | [73] | |
C. trachomatis | FGD5-AS1 | Up | Upregulated FGD5-AS1 provides new ideas for screening potential intervention targets for C. trachomati | [66] |
lncRNA-IRF1 | Up | MIAT and IRF1 are involved in apoptosis resistance in persistent infection | [74] | |
MIAT | Up | [74] | ||
ZEB1-AS1 | Up | A persistent C. trachomatis infection up-regulated lncRNA that could enhance persistent infection-induced anti-apoptosis | [74] | |
ZFAS1 | Up | Plays a role in the anti-apoptotic process of C. trachomatis | [75] | |
E. coli | LRRC75A | Down | Knockout of LRRC75A-AS1 attenuated the E. coli-induced inflammatory responses | [76] |
H. pylori | lncRNA GNAT1-1 | Down | Regulation of invasion and migration of gastric cancer cells | [53] |
ZFAS1 | Up | Upregulation of lncRNA ZFAS1 predicts poor prognosis and promotes invasion and metastasis in colorectal cancer | [77] | |
L. monocytogenes | lincRNA-EPS | Down | Downregulation of lincRNA-EPS leads to an increased production of proinflammatory cytokines and iNOS in splenic and liver macrophages and dendritic cells | [63] |
lncRNA-SROS1 | Down | Shows potential as biomarkers in the disease progression | [71] | |
lincRNA-Cox2 | Up | [78] | ||
AS-IL1α | Up | An important regulator of IL-1α transcription during the innate immune response, and has the potential to be used as a diagnostic marker | [79] | |
M. bovis | lincRNA-Cox2 | Up | Shows potential as biomarkers in the disease progression | [78] |
lincRNA-EPS | Down | [80] | ||
MEG3 | Down | Shows potential as a biomarker in the systematic early diagnosis | [81] | |
M. smegmatis | MEG3 | Up | As a novel mediator of host cell response during mycobacterial infections | [70] |
M. tuberculosis | XLOC_012582 | Up | These deregulated lncRNAs in Mtb-infected cells can be introduced as promising molecular biomarkers for prognosis and/or diagnosis | [56] |
PCED1B-AS1 | Up | [56] | ||
lncRNA-CD244 | Up | A major regulator of CD8 T-cell immune response during in vivo Mtb infection and has the potential to be used as a diagnostic marker | [68] | |
NEAT1 | Down | Tuberculosis patients had significantly increased the expression of NEAT1, and NEAT1 might serve as a potential indicator for patient prognosis of tuberculosis | [69] | |
S. aureus | TNK2-AS1 | Up | TNK2-AS1 could be regarded as stable markers associated with bovine S. aureus mastitis | [51] |
S. typhimurium | NEAT1_2 | Up | Shows potential as biomarkers in the systematic early diagnosis | [61] |
IFNG-AS1 | Up | [82] |
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Shi, L.; Han, X.; Liu, F.; Long, J.; Jin, Y.; Chen, S.; Duan, G.; Yang, H. Review on Long Non-Coding RNAs as Biomarkers and Potentially Therapeutic Targets for Bacterial Infections. Curr. Issues Mol. Biol. 2024, 46, 7558-7576. https://doi.org/10.3390/cimb46070449
Shi L, Han X, Liu F, Long J, Jin Y, Chen S, Duan G, Yang H. Review on Long Non-Coding RNAs as Biomarkers and Potentially Therapeutic Targets for Bacterial Infections. Current Issues in Molecular Biology. 2024; 46(7):7558-7576. https://doi.org/10.3390/cimb46070449
Chicago/Turabian StyleShi, Liqin, Xueya Han, Fang Liu, Jinzhao Long, Yuefei Jin, Shuaiyin Chen, Guangcai Duan, and Haiyan Yang. 2024. "Review on Long Non-Coding RNAs as Biomarkers and Potentially Therapeutic Targets for Bacterial Infections" Current Issues in Molecular Biology 46, no. 7: 7558-7576. https://doi.org/10.3390/cimb46070449