Aquaporin Modulation by Cations, a Review
Abstract
:1. Introduction
2. Modulation by Alkaline Earth Metal Cations
2.1. Calcium Ions
2.2. Magnesium Ions
3. Transition Metals
3.1. Mercury Ions
3.2. Zinc Ions
3.3. Cadmium Ions
3.4. Gold Ion Compounds
3.5. Silver Ions
3.6. Copper Ions
3.7. Nickel Ions
3.8. Lead Ions
3.9. Manganese Ions
3.10. Iron Ions
4. Alkaline Metals
4.1. Lithium Ions
4.2. Sodium Ions
5. Discussion
Supplementary Materials
Author Contributions
Funding
Conflicts of Interest
References
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Ion Name | Name of the Regulated AQP | Direct Interaction with AQP | Water Channel Function | Residues Involved in Binding | Residues Involved in Molecular Mechanism | Transcripts and/or Protein Abundance |
---|---|---|---|---|---|---|
Calcium | SoPIP2;1 | yes | inhibition [31] | D28 and E31 [31] T183 and A267 [60] | D28, E31, R190, R191 and H193 [31,57] | Unknown |
Calcium | SoPIP2;1 | No | Activation | None | S115, S188 and S274 [31,58,59] | unknown |
Calcium | AtPIP2;1 | Yes | Inhibition | E31, H199 [62] | E31, H199 and R124 [62] | unknown |
Calcium | Human AQP2 | yes | Unknown | Q57, E155 [56,63] | Unknown | increase [50,165] |
Calcium | Ovine AQP0 Human AQP0 | No | Inhibition | None | L227, L234, A240 and R156 (CaM binding) [41,55] S229, S231 and S235 (phosphorylation sites) [46] R187, Y149, Y23 (water permeability modulation) [45,54] | unknown |
Calcium | Human AQP4 | No | Unknown | None | Residues 6-31 in AQP4-M1 residues 256-280 in AQP4-M1 (CaM binding) [49] | unknown |
Calcium | Mouse AQP6 rat AQP6 human AQP6 | No | Unknown | None | L15, L19, A22 and F28 in human AQP6 [48] | unknown |
Magnesium | Human AQP3 | Unknown | Unknown | Unknown | Unknown | increase [67,68,69] |
Magnesium | Rat AQP4 human AQP4 | Unknown | Unknown | Unknown | Unknown | No effect or decrease [70,71,72,73] |
Mercury | E. coli AQPZ | yes | Inhibition | C20 [82] | C20 [82] R189 [92] | unknown |
Mercury | Human AQP3 | yes | Inhibition | C40 | F63, R218 [86] | Decrease (rat AQP3) [95] |
Mercury | Human AQP1 bovine AQP1 | yes | Inhibition | Human: C189 [80] bovine: C191 [88] | For bovine AQP1: R197, H182, F58, I193, G192, C191, G190, E144 [88] | Unknown |
Mercury | Human AQP2 | yes | Inhibition | C181 [87] | Unknown | unknown |
Mercury | rat AQP4 | yes | Inhibition | C178 [83] | Unknown | Decrease [95] |
Mercury | Rat AQP6 | yes | Activation | C155 and C190 [85,90] | R196 [92] and M160 [91] | No effect |
Mercury | AtTIPs | Yes | Inhibition | C116 or C118 [93] | C116 or C118 [93] | unknown |
Mercury | Rat AQP7 | Unknown | Unknown | Unknown | Unknown | decrease [95] |
Zinc | bovine AQP0 human AQP0 | yes | Activation | H40 and H122 [101] C144, T54, Q140 [102] | R187 [102] | unknown |
Zinc | Human AQP5 | yes | Activation | C145, S149, S164, S168, T55, Q58 [102] | Human: R187 [102] | increase [104] |
Zinc | Rat AQP4 Human AQP4 | yes | Inhibition | Rat: C178 [105] human: C253, D179, H90 [102] | Human: R216 [102] | unknown |
Zinc | Human AQP2 | yes | Inhibition | C75 [102] | R216 [102] | unknown |
Zinc | Soybean AQPs | Unknown | Unknown | Unknown | Unknown | No effect or increase [106] |
Zinc | Barley AQPs (HvPIP1;3, HvPIP2;4 and HvPIP2;5) | Unknown | Unknown | Unknown | Unknown | decrease [107] |
Zinc | Pak choi AQPs (PIP1 isoforms) | unknown | Unknown | Unknown | Unknown | increase [108] |
Zinc | Human AQP3 | No | No effect [124] | None | None | unknown |
Cadmium | Human AQP2 | Yes | Unknown | Q57, E155 [63] | Unknown | unknown |
Cadmium | SoPIP2;1 | Yes | Inhibition | D28 and E31 [31] T183 and A267 [60] | D28, E31, R190, R191 and H193 [31,57] | unknown |
Cadmium | AtPIP2;1 | Yes | Inhibition | E31 and H199 [62] | E31, H199 and R124 [62] | unknown |
Cadmium | Human AQP3 | No | No effect [124] | None | None | Unknown |
Gold | Human AQP3 | yes | Inhibition | C40 [114] | R218 [114] | unknown |
Gold | Human AQP7 | yes | Inhibition | Met47 [117] | unknown | Unknown |
Gold | mouse AQP1 | Unknown | Unknown | Unknown | Unknown | increase [118] |
Silver | Soybean NOD26 | Unknown | inhibition [119] | Unknown | Unknown | unknown |
Silver | Beet root PIPs | Unknown | inhibition [119] | Unknown | Unknown | unknown |
Silver | Human AQP1 and human AQP3 | Unknown | Inhibition [119] | Unknown | Unknown | unknown |
Silver | Soybean AQPs | Unknown | Unknown | Unknown | Unknown | No effect or increase [106] |
Copper | Human AQP3 | Unknown | inhibition | unknown | W128, S152, H241 [122] | Unknown |
Copper | Human AQP4 | no | No effect [122] | None | none | unknown |
Copper | Mouse AQP7 | no | No effect [122] | None | none | Unknown |
Nickel | Human AQP3 | Unknown | Inhibition | unknown | W128, S152, H241 [124] | Unknown |
Nickel | Human AQP4 | no | No effect [124] | none | none | unknown |
Nickel | Human AQP5 | no | No effect [124] | None | None | unknown |
Nickel | AtPIP2;1 | Yes | Inhibition [62] | Unknown | unknown | unknown |
Lead | Mouse AQP4 | unknown | Activation | Unknown | S111 [128] | No effect [128] |
Lead | Human AQP3 | No | No effect [128] | None | None | unknown |
Manganese | AtPIP2;1 | Yes | Inhibition | E31 and H199 [62] | E31, H199 and R124 [62] | unknown |
Manganese | Rat AQP2 | Unknown | Inhibition [133] | Unknown | Unknown | unknown |
Manganese | Rat AQP4 | Unknown | Activation [134] | Unknown | Unknown | No effect |
Iron | Mouse AQP4 rat AQP4 | Unknown | Unknown | Unknown | Unknown | increase [138,139,140,141] |
Iron | Mouse AQP9 | Unknown | Unknown | Unknown | Unknown | increase [138] |
Lithium | Human AQP2 [146] rat AQP2 [144,145,148,149] mouse AQP2 [147,150] | Unknown | Unknown | Unknown | Unknown | decrease [144,145,146,147,148,149,150] |
Lithium | Rat AQP3 | Unknown | Unknown | Unknown | Unknown | decrease [144] |
Lithium | Rat AQP1 | Unknown | Unknown | Unknown | Unknown | No effect [144] |
Sodium | Rat AQP2 [151,154,156] human AQP2 [152,153,155] | yes [157] | Unknown | E106, D111, D115, D199 and D200 in human AQP2 [157] | Unknown | Conflicting results: decrease [151] increase [152,153,154,155,156] |
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Mom, R.; Mocquet, V.; Auguin, D.; Réty, S. Aquaporin Modulation by Cations, a Review. Curr. Issues Mol. Biol. 2024, 46, 7955-7975. https://doi.org/10.3390/cimb46080470
Mom R, Mocquet V, Auguin D, Réty S. Aquaporin Modulation by Cations, a Review. Current Issues in Molecular Biology. 2024; 46(8):7955-7975. https://doi.org/10.3390/cimb46080470
Chicago/Turabian StyleMom, Robin, Vincent Mocquet, Daniel Auguin, and Stéphane Réty. 2024. "Aquaporin Modulation by Cations, a Review" Current Issues in Molecular Biology 46, no. 8: 7955-7975. https://doi.org/10.3390/cimb46080470