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Article

An Experimental Murine Model to Study Lipoatrophia Semicircularis

by
María Angustias Palomar-Gallego
1,2,
Julio Ramiro-Bargueño
3,
Esther Cuerda-Galindo
4,
Rafael Linares-García-Valdecasas
1,
Stella M. Gómez-Sánchez
1,2,
José Delcan
1,2 and
Gema Díaz-Gil
1,2,*
1
Department of Basic Health Sciences, Universidad Rey Juan Carlos, 28922 Alcorcón, Spain
2
Grupo de Investigación Emergente de Bases Anatómicas, Moleculares y del Desarrollo Humano de la Universidad Rey Juan Carlos (GAMDES), 28922 Alcorcón, Spain
3
Department of Signal Theory, Communications and Telematic Systems and Computing, Universidad Rey Juan Carlos, 28942 Fuenlabrada, Spain
4
Private Practice Consultation Ber-Matologie, Albrechtstraße 50, 12167 Berlin, Germany
*
Author to whom correspondence should be addressed.
Curr. Issues Mol. Biol. 2024, 46(8), 7986-7996; https://doi.org/10.3390/cimb46080472
Submission received: 19 June 2024 / Revised: 19 July 2024 / Accepted: 24 July 2024 / Published: 25 July 2024
(This article belongs to the Section Biochemistry, Molecular and Cellular Biology)

Abstract

Lipoatrophia semicircularis is a benign pathology characterized by subcutaneous tissue atrophy that affects the skin and related structures. Its etiology remains unclear; however, in the recent few years, it has been proposed that electrostatic charges could be a potential factor. Based on this hypothesis, the aim of this work is to study the cause–effect relation between electrostatic energy and LS, providing insights into the molecular mechanisms. For this purpose, an experimental murine model was created using obese mice. One group served as a control and the other groups involved charging clothes with varying connections to the ground: through the skin, through the clothes or not connected to the ground). Skin biopsies showed that the most significant lesions, including lipophagic granulomas with inflammatory infiltrate, were found in the first group (connected to the ground through the skin). Lipophagic reactions without an inflammatory infiltrate were observed in the other groups subjected to electrical discharges. In the control mice, no histological changes were observed. Oxidative processes were also measured in lower limbs tissue. Malondialdehyde levels significantly increased in the lower limbs after electrostatic discharges. However, the presence of ground through a wire attached to highly conductive clothes around the thigh significantly reduced the effect of electrostatic charges on lipid peroxidation. To our knowledge, this is the first study in which an experimental model has been used to reproduce LS induced by electrostatic energy, suggesting a cause–effect relationship between electrostatic charge and discharge with fat tissue lesion.
Keywords: lipoatrophia semicircularis; electrostatic energy; fat tissue; lipid peroxidation lipoatrophia semicircularis; electrostatic energy; fat tissue; lipid peroxidation

Share and Cite

MDPI and ACS Style

Palomar-Gallego, M.A.; Ramiro-Bargueño, J.; Cuerda-Galindo, E.; Linares-García-Valdecasas, R.; Gómez-Sánchez, S.M.; Delcan, J.; Díaz-Gil, G. An Experimental Murine Model to Study Lipoatrophia Semicircularis. Curr. Issues Mol. Biol. 2024, 46, 7986-7996. https://doi.org/10.3390/cimb46080472

AMA Style

Palomar-Gallego MA, Ramiro-Bargueño J, Cuerda-Galindo E, Linares-García-Valdecasas R, Gómez-Sánchez SM, Delcan J, Díaz-Gil G. An Experimental Murine Model to Study Lipoatrophia Semicircularis. Current Issues in Molecular Biology. 2024; 46(8):7986-7996. https://doi.org/10.3390/cimb46080472

Chicago/Turabian Style

Palomar-Gallego, María Angustias, Julio Ramiro-Bargueño, Esther Cuerda-Galindo, Rafael Linares-García-Valdecasas, Stella M. Gómez-Sánchez, José Delcan, and Gema Díaz-Gil. 2024. "An Experimental Murine Model to Study Lipoatrophia Semicircularis" Current Issues in Molecular Biology 46, no. 8: 7986-7996. https://doi.org/10.3390/cimb46080472

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