Keratins 6, 16, and 17 in Health and Disease: A Summary of Recent Findings
Abstract
:1. Introduction
2. Structure and Localization of K6/K16/K17
3. K6, K16, and K17 Are Essential for Regeneration
4. K6, K16, and K17 Are Involved in the Pathogenesis of Various Skin Diseases
4.1. Psoriasis
4.2. Atopic Dermatitis
4.3. Pachyonychia Congenita
4.4. Other Skin Pathologies
5. Cancer
6. The Role of K6, K16, and K17 in Carcinogenesis
7. Cell Functions of K6, K16, and K17
8. Regulation of K6, K16, and K17
Funding
Data Availability Statement
Conflicts of Interest
References
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Cancer Type | Gene | References | ||
---|---|---|---|---|
KRT17 | KRT16 | KRT6 | ||
Oral squamous cell carcinoma (OSCC) | + | + | + | [13,87] |
Lung adenocarcinoma (LUAD) | + | + | + | [15,80,84] |
Invasive breast carcinoma (BRCA) | +/− | + | [88,89] | |
Ovarian cancer | + | + | [90,91] | |
Urothelial carcinoma (UCC) | + | + | [92] | |
Bladder cancer | + | [93] | ||
Gastric cancer | + | + | [78,94] | |
Pancreatic ductal adenocarcinoma (PDAC) | + | + | [81,95,96] | |
Esophageal cancer (ESCC) | + | + | [97,98] | |
Tylosis with esophageal cancer (TOC) | + | [98] | ||
Hypopharyngeal squamous carcinoma (HSCC) | − | [99] | ||
Colorectal cancer (CRC) | + | + | [82,86] | |
Lung squamous cell carcinoma (LSCC) | + | [80] | ||
Cervical cancer (CC) | + | [100] | ||
Endometrial carcinoma | + | [74] | ||
Chromophobe renal cell carcinoma (KICH) | + | [16] | ||
Papillary renal cell carcinoma (KIRP) | n.d. | [16] | ||
Pancreatic adenocarcinoma (PAAD) | n.d. | [16] | ||
Thyroid cancer | + | [101] | ||
Basal cell carcinoma (BCC) | + | [102] | ||
Basaloid follicular hamartoma (BFH) | + | [102] | ||
Head and neck squamous cell carcinoma (HNSCC) | + | [79,103] | ||
Cutaneous squamous cell carcinoma (cSCC) | + | + | + | [104,105,106] |
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Romashin, D.D.; Tolstova, T.V.; Varshaver, A.M.; Kozhin, P.M.; Rusanov, A.L.; Luzgina, N.G. Keratins 6, 16, and 17 in Health and Disease: A Summary of Recent Findings. Curr. Issues Mol. Biol. 2024, 46, 8627-8641. https://doi.org/10.3390/cimb46080508
Romashin DD, Tolstova TV, Varshaver AM, Kozhin PM, Rusanov AL, Luzgina NG. Keratins 6, 16, and 17 in Health and Disease: A Summary of Recent Findings. Current Issues in Molecular Biology. 2024; 46(8):8627-8641. https://doi.org/10.3390/cimb46080508
Chicago/Turabian StyleRomashin, Daniil D., Tatiana V. Tolstova, Alexandra M. Varshaver, Peter M. Kozhin, Alexander L. Rusanov, and Natalia G. Luzgina. 2024. "Keratins 6, 16, and 17 in Health and Disease: A Summary of Recent Findings" Current Issues in Molecular Biology 46, no. 8: 8627-8641. https://doi.org/10.3390/cimb46080508