The Role of Mannitol and Vitamin D in Ovarian Ischemia/Reperfusion Injury in Rats with Acute Abdominal
Abstract
:1. Introduction
2. Materials and Methods
2.1. Study Design
2.2. Experimental Procedures
2.3. Measurements
2.4. Statistical Analysis
3. Results
4. Discussion
5. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
Abbreviations
I/R | Ischemia–reperfusion injury |
PCNA | Proliferating Cell Nuclear Antigen |
TAS | Total antioxidant status |
TOS | Total oxidant status |
OSI | Oxidative stress index |
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Control | I/R | I/R + M | I/R + D | I/R + D + M | |
---|---|---|---|---|---|
TAS (mmol/L) | 1.32 ± 0.14 | 1.07 ± 0.01 | 1.09 ± 0.04 | 1.07 ± 0.05 | 1.07 ± 0.04 |
TOS (mmol/L) | 24.90 ± 7.2 | 57.94 ± 6.6 a** | 29.02 ± 5.6 b,c* | 42.53 ± 4.5 c** | 16.16 ± 1.3 b*** |
OSI (TOS/TAS) | 18.08 ± 4.8 | 54.22 ± 6.6 a*** | 25.83 ± 4.1 b**,c* | 39.14 ± 3.2 b*,c** | 14.94 ± 1.0 b*** |
PCNA | 2.91 ± 0.02 | 1.16 ± 0.02 a*** | 2.40 ± 0.06 b***,c* | 2.02 ± 0.16 b,c** | 2.75 ± 0.05 b*** |
Control | I/R | I/R + M | I/R + D | I/R + M + D | |
---|---|---|---|---|---|
Primordial fc | 5.28 ± 0.29 | 0.63 ± 0.04 a*** | 3.40 ± 0.08 b*** | 3.32 ± 0.11 b*** | 3.71 ± 0.02 b*** |
Primary fc | 3.78 ± 0.07 | 0.68 ± 0.03 a*** | 3.28 ± 0.06 b***, c** | 2.53 ± 0.04 b*** | 2.42 ± 0.18 b*** |
Preantral fc | 6.10 ± 0.18 | 4.62 ± 0.20 a*** | 6.35 ± 0.05 b***, c** | 6.92 ± 0.16 b,c*** | 5.50 ± 0.13 b** |
Antral fc | 5.51 ± 0.19 | 4.03 ± 0.09 a*** | 7.15 ± 0.06 b,c*** | 5.62 ± 0.04 b*** | 5.88 ± 0.16 b*** |
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Karateke, F.; Karateke, A.; Topdagi, B.; Atilgan, M.; Dokuyucu, R. The Role of Mannitol and Vitamin D in Ovarian Ischemia/Reperfusion Injury in Rats with Acute Abdominal. Curr. Issues Mol. Biol. 2024, 46, 8903-8913. https://doi.org/10.3390/cimb46080526
Karateke F, Karateke A, Topdagi B, Atilgan M, Dokuyucu R. The Role of Mannitol and Vitamin D in Ovarian Ischemia/Reperfusion Injury in Rats with Acute Abdominal. Current Issues in Molecular Biology. 2024; 46(8):8903-8913. https://doi.org/10.3390/cimb46080526
Chicago/Turabian StyleKarateke, Faruk, Atilla Karateke, Basak Topdagi, Merve Atilgan, and Recep Dokuyucu. 2024. "The Role of Mannitol and Vitamin D in Ovarian Ischemia/Reperfusion Injury in Rats with Acute Abdominal" Current Issues in Molecular Biology 46, no. 8: 8903-8913. https://doi.org/10.3390/cimb46080526