Apoptotic Receptors and CD107a Expression by NK Cells in an Interaction Model with Trophoblast Cells
Abstract
:1. Introduction
2. Materials and Methods
2.1. Cell Lines
2.2. Inductors
2.3. Conditioned Media (CM) of Chorionic Villi Explants
2.4. Determination of NK-92 Cell Expression of Proapoptotic Receptors after Incubation with JEG-3 Trophoblast Cells and Inducers
2.5. Statistical Data Analysis
3. Results
3.1. Expression of Proapoptotic Receptors and Their Ligands by NK-92 Cells in the Presence of Cytokines
3.2. Expression of Proapoptotic Receptors and Their Ligands by NK-92 Cells in the Presence of Trophoblast Cells and Cytokines
3.3. Expression of Proapoptotic Receptors and Their Ligands by NK-92 Cells in the Presence of Chorionic Villi CM
3.4. Expression of Proapoptotic Receptors and Ligands of NK-92 Cells in the Presence of Trophoblast Cells and Chorionic Villi CM
4. Discussion
5. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
References
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Mikhailova, V.A.; Sokolov, D.I.; Grebenkina, P.V.; Bazhenov, D.O.; Nikolaenkov, I.P.; Kogan, I.Y.; Totolian, A.A. Apoptotic Receptors and CD107a Expression by NK Cells in an Interaction Model with Trophoblast Cells. Curr. Issues Mol. Biol. 2024, 46, 8945-8957. https://doi.org/10.3390/cimb46080528
Mikhailova VA, Sokolov DI, Grebenkina PV, Bazhenov DO, Nikolaenkov IP, Kogan IY, Totolian AA. Apoptotic Receptors and CD107a Expression by NK Cells in an Interaction Model with Trophoblast Cells. Current Issues in Molecular Biology. 2024; 46(8):8945-8957. https://doi.org/10.3390/cimb46080528
Chicago/Turabian StyleMikhailova, Valentina A., Dmitry I. Sokolov, Polina V. Grebenkina, Dmitry O. Bazhenov, Igor P. Nikolaenkov, Igor Yu. Kogan, and Areg A. Totolian. 2024. "Apoptotic Receptors and CD107a Expression by NK Cells in an Interaction Model with Trophoblast Cells" Current Issues in Molecular Biology 46, no. 8: 8945-8957. https://doi.org/10.3390/cimb46080528