The Potential Therapeutic Effects of Tadalafil on the Endothelium in a Subarachnoid Hemorrhage Animal Model: Insights from Immunohistochemical Staining
Abstract
:1. Introduction
2. Materials and Methods
2.1. Experimental Animal and Grouping
2.2. Induction of SAH in Experimental Animals and Administration of Drugs
2.3. H&E and IHC Staining
2.4. IHC Analysis and Statistical Analysis
3. Results
3.1. H&E and IHC Staining Findings
3.2. Phenotypic Scoring of BCL2 and Bax Expression
4. Discussion
5. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
References
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Group (n) | Bcl2 Staining Score (Average ± SD) | p † | Bax Staining Score(Average ± SD) | p † | Groupwise Comparison | |||
---|---|---|---|---|---|---|---|---|
Group | p ‡ | p § | ||||||
Basilar artery | C (15) | 1.07 ± 1.03 | <0.001 | 0 | <0.001 | C vs. S | <0.001 | <0.001 |
S (13) | 4.77 ± 1.17 | 3.31 ± 1.49 | C vs. N | 0.002 | 0.001 | |||
N (14) | 3.57 ± 1.40 | 2.43 ± 1. 65 | S vs. N | 0.311 | 0.720 | |||
Penetrated arteriole | C (19) | 1.70 ± 0.95 | <0.001 | 0 | <0.001 | C vs. S | <0.001 | <0.001 |
S (24) | 4.65 ± 1.27 | 4.00 ± 2.41 | C vs. N | 0.001 | 1.000 | |||
N (21) | 4.15 ± 1.40 | 1.40 ± 1.39 | S vs. N | 0.724 | <0.001 |
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Park, K.H.; Kwon, H.-J.; Jeong, E.-O.; Koh, H.-S.; Lim, J. The Potential Therapeutic Effects of Tadalafil on the Endothelium in a Subarachnoid Hemorrhage Animal Model: Insights from Immunohistochemical Staining. Curr. Issues Mol. Biol. 2024, 46, 9555-9564. https://doi.org/10.3390/cimb46090567
Park KH, Kwon H-J, Jeong E-O, Koh H-S, Lim J. The Potential Therapeutic Effects of Tadalafil on the Endothelium in a Subarachnoid Hemorrhage Animal Model: Insights from Immunohistochemical Staining. Current Issues in Molecular Biology. 2024; 46(9):9555-9564. https://doi.org/10.3390/cimb46090567
Chicago/Turabian StylePark, Kwang Hyon, Hyon-Jo Kwon, Eun-Oh Jeong, Hyeon-Song Koh, and Jeongwook Lim. 2024. "The Potential Therapeutic Effects of Tadalafil on the Endothelium in a Subarachnoid Hemorrhage Animal Model: Insights from Immunohistochemical Staining" Current Issues in Molecular Biology 46, no. 9: 9555-9564. https://doi.org/10.3390/cimb46090567