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10.3390/cimb47020105
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Article

Study on the Effects and Mechanism of Corilagin on A2780 Cell Apoptosis

by
Ziyang Xu
1,
Yuhan Jiang
2,
Tiantian Shan
1,
Lei Hu
1,
Minrui Wu
1,
Hanxu Ji
1,
Longjie Li
1,
Yang Yi
3,
Hongxun Wang
1 and
Limei Wang
1,*
1
College of Life Science and Technology, Wuhan Polytechnic University, Wuhan 430023, China
2
College of Life and Science, Huazhong University of Science and Technology, Wuhan 430023, China
3
College of Food Science and Engineering, Wuhan Polytechnic University, Wuhan 430023, China
*
Author to whom correspondence should be addressed.
Curr. Issues Mol. Biol. 2025, 47(2), 105; https://doi.org/10.3390/cimb47020105
Submission received: 2 January 2025 / Revised: 30 January 2025 / Accepted: 30 January 2025 / Published: 7 February 2025
(This article belongs to the Section Bioorganic Chemistry and Medicinal Chemistry)
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Abstract

Previous studies have demonstrated corilagin’s inhibitory effects on the growth of various cancer cells. Given the limited research on corilagin’s impact on ovarian cancer, a particularly deadly gynecological malignancy, this study aimed to investigate corilagin’s influence on A2780 ovarian cancer cell apoptosis and its underlying mechanisms. The goal was to evaluate corilagin’s potential as a therapeutic agent for ovarian cancer. The results of the CCK-8 assay showed that corilagin inhibited the proliferation of A2780 ovarian cancer cells while exhibiting lower toxicity to normal ovarian surface epithelial cells (IOSE-80). We found that corilagin significantly altered the A2780 cell cycle, decreasing the proportion of cells in the G0/G1 and G2/M phases and inducing cell cycle arrest in the S phase. At low concentrations, corilagin induced apoptosis in A2780 cells, accompanied by a decline in mitochondrial membrane potential and calcium influx. Transcriptome sequencing analysis identified differentially expressed apoptosis-related genes in corilagin-treated A2780 cells, primarily within the PI3K-AKT pathway. Furthermore, qPCR and Western blot results confirmed the upregulation of p53 and Bax genes and the downregulation of BCL-2. Corilagin also increased the expression of apoptotic factors caspase-9, caspase-3, PUMA, and cytochrome C, indicating its ability to induce apoptosis. Overall, corilagin effectively inhibited A2780 cell proliferation, induced cell cycle arrest, and triggered apoptosis. Its anti-tumor effect in vitro suggests its potential as a therapeutic agent for ovarian cancer A2780, especially through the PI3K/p53 pathway.
Keywords: corilagin; ovarian cancer; apoptosis; mechanism; p53 signaling pathway corilagin; ovarian cancer; apoptosis; mechanism; p53 signaling pathway

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MDPI and ACS Style

Xu, Z.; Jiang, Y.; Shan, T.; Hu, L.; Wu, M.; Ji, H.; Li, L.; Yi, Y.; Wang, H.; Wang, L. Study on the Effects and Mechanism of Corilagin on A2780 Cell Apoptosis. Curr. Issues Mol. Biol. 2025, 47, 105. https://doi.org/10.3390/cimb47020105

AMA Style

Xu Z, Jiang Y, Shan T, Hu L, Wu M, Ji H, Li L, Yi Y, Wang H, Wang L. Study on the Effects and Mechanism of Corilagin on A2780 Cell Apoptosis. Current Issues in Molecular Biology. 2025; 47(2):105. https://doi.org/10.3390/cimb47020105

Chicago/Turabian Style

Xu, Ziyang, Yuhan Jiang, Tiantian Shan, Lei Hu, Minrui Wu, Hanxu Ji, Longjie Li, Yang Yi, Hongxun Wang, and Limei Wang. 2025. "Study on the Effects and Mechanism of Corilagin on A2780 Cell Apoptosis" Current Issues in Molecular Biology 47, no. 2: 105. https://doi.org/10.3390/cimb47020105

APA Style

Xu, Z., Jiang, Y., Shan, T., Hu, L., Wu, M., Ji, H., Li, L., Yi, Y., Wang, H., & Wang, L. (2025). Study on the Effects and Mechanism of Corilagin on A2780 Cell Apoptosis. Current Issues in Molecular Biology, 47(2), 105. https://doi.org/10.3390/cimb47020105

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