Analysis of the Efficiency and Prognostic Value of the Sentinel Node Technique in Oral Squamous Cell Carcinoma after Seven Years
Abstract
:1. Introduction
2. Materials and Methods
2.1. Study Design
2.2. Calculation of Sample Size
2.3. Study Population, Inclusion, and Exclusion Criteria
2.4. Marking and Study of the Tumour’s Lymphatic Drainage
2.5. Histopathological Study of Sentinel Nodes (SN)
2.6. Information and Variables
2.7. Statistical Analysis
3. Results
4. Discussion
5. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Conflicts of Interest
References
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Variables | Number | % | |
---|---|---|---|
Gender | Male | 28 | 46.7 |
Female | 32 | 53.3 | |
Location | Tongue | 24 | 40.0 |
Floor of mouth | 13 | 21.7 | |
Buccal mucosa | 8 | 13.3 | |
Retromolar trigone | 3 | 5.0 | |
Gum | 4 | 6.7 | |
Hard palate | 1 | 1.7 | |
Soft palate | 1 | 1.7 | |
Alveolar ridge | 5 | 8.3 | |
Upper lip | 1 | 1.7 | |
TNM(Tumor, Nodes, Metastases) | T1 | 32 | 53.3 |
T2 | 28 | 46.7 | |
SN (Sentinel Node) | Negative | 50 | 83.3 |
Positive | 10 | 16.7 | |
Neck Metastasis Post-SN | No | 46 | 76.7 |
Yes | 14 | 23.3 | |
Histopathological Lymph Node Description | Negative | 50 | 83.3 |
Micrometastasis | 2 | 3.3 | |
Macrometastasis | 8 | 13.3 | |
Histopathological Lymph Node Affectation | Subcapsular | 8 | (80) |
Intraparenchymal | 1 | (10) | |
Complete (both) | 1 | (10) | |
Extracapsular Affectation | No | 9 | (90) |
Yes | 1 | (10) | |
Neck Treatment | No treatment | 50 | 83.3 |
Functional dissection | 10 | 16.7 | |
Development | Stable | 32 | 53.3 |
Relapse | 17 | 28.3 | |
Recurring Relapse | 1 | 1.7 | |
Death | 10 | 16.7 | |
Locoregional Recurrence | No | 38 | 63.3 |
Yes | 22 | 36.7 | |
Death | No | 42 | 70.0 |
Yes | 12 | 20.0 | |
Yes, for other reasons | 6 | 10.0 |
Average (SD) | Minimum-Maximum | |
---|---|---|
Age of Diagnosis (Years) | 66.9 (12.3) | 34.9–92.0 |
SN Size (cm2) | 1.7 (2.7) | 0.1–17.6 |
Follow-up Time (months)
| 42.8 (23.1) 43.8 (21.8) 38.1 (29.7) | 0.6–87.3 0.6–82.8 6.7–87.3 |
Specific Survival (months)
| 24.8 (19.3) 27.2 (22.8) 21.1 (12.5) | 0.6–76.6 0.6–82.8 6.7–43.5 |
Disease-Free Survival (months)
| 15.9 (13.3) 17.0 (15.1) 13.6 (8.9) | 1.8–61.3 3.9–61-3 1.8–29.9 |
Covariate | Death | |||
---|---|---|---|---|
Univariate OR (95% CI) | p Value | Adjusted OR (95% CI) | p Value | |
SLN (Sentinel Lymph Node) | ||||
Positive vs. Negative | 11.00 (2.39–50.59) | 0.002 | 28.75 (2.71–305.62) | 0.005 |
Location | ||||
Other vs. Tongue | 4.23 (0.84–21.40) | 0.081 | 18.61 (1.34–258.65) | 0.029 |
TNM | ||||
T2 vs. T1 | 4.58 (1.10–19.11) | 0.037 | 5.15 (0.86–30.72) | 0.072 |
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Suárez-Ajuria, M.; García-García, A.; Suárez-Peñaranda, J.M.; Garrido-Pumar, M.; Chamorro-Petronacci, C.M.; Somoza-Martín, J.M.; Pérez-Sayáns, M. Analysis of the Efficiency and Prognostic Value of the Sentinel Node Technique in Oral Squamous Cell Carcinoma after Seven Years. Medicina 2021, 57, 1092. https://doi.org/10.3390/medicina57101092
Suárez-Ajuria M, García-García A, Suárez-Peñaranda JM, Garrido-Pumar M, Chamorro-Petronacci CM, Somoza-Martín JM, Pérez-Sayáns M. Analysis of the Efficiency and Prognostic Value of the Sentinel Node Technique in Oral Squamous Cell Carcinoma after Seven Years. Medicina. 2021; 57(10):1092. https://doi.org/10.3390/medicina57101092
Chicago/Turabian StyleSuárez-Ajuria, Maria, Abel García-García, José M. Suárez-Peñaranda, Miguel Garrido-Pumar, Cintia M. Chamorro-Petronacci, José M. Somoza-Martín, and Mario Pérez-Sayáns. 2021. "Analysis of the Efficiency and Prognostic Value of the Sentinel Node Technique in Oral Squamous Cell Carcinoma after Seven Years" Medicina 57, no. 10: 1092. https://doi.org/10.3390/medicina57101092