The Influence of Dental Status and Blood Parameters Characterizing Endogenous Intoxication on the Timing of Childbirth
Abstract
:1. Introduction
2. Materials and Methods
3. Results
4. Discussion
5. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
- Alnasser, B.H.; Alkhaldi, N.K.; Alghamdi, W.K.; Alghamdi, F.T. The Potential Association Between Periodontal Diseases and Adverse Pregnancy Outcomes in Pregnant Women: A Systematic Review of Randomized Clinical Trials. Cureus 2023, 15, e33216. [Google Scholar] [CrossRef]
- Beck, J.D.; Offenbacher, S. Systemic effects of periodontitis: Epidemiology of periodontal disease and cardiovascular disease. J. Periodontol. 2005, 76 (Suppl. S11), 2089–2100. [Google Scholar] [CrossRef] [PubMed]
- Surya, J.P. Causal relationship between periodontitis and chronic obstructive pulmonary disease. J. Indian Soc. Periodontol. 2011, 15, 359–365. [Google Scholar] [CrossRef]
- AlSharief, M.; Alabdurubalnabi, E. Periodontal Pathogens and Adverse Pregnancy Outcomes: A Narrative Review. Life 2023, 13, 1559. [Google Scholar] [CrossRef]
- Chowdhury, S.F.; Islam, M.N. Periodontal diseases among pregnant women attending an antenatal clinic at Dhaka, Bangladesh. J. Oral Res. 2021, 10, 1–10. [Google Scholar] [CrossRef]
- Nannan, M.; Xiaoping, L.; Ying, J. Periodontal disease in pregnancy and adverse pregnancy outcomes: Progress in related mechanisms and management strategies. Front. Med. 2022, 9, 963956. [Google Scholar] [CrossRef]
- Shanker, R.K.; Mohamed, M.; Hegle, S.; Kumar, M.S. Influence of personality traits on gingival health. J. Indian Soc. Periodontal. 2013, 17, 58–62. [Google Scholar]
- Wu, M.; Chen, S.W.; Jiang, S.Y. Relationship between gingival inflammation and pregnancy. Mediators Inflamm. 2015, 2015, 623427. [Google Scholar] [CrossRef]
- Pozo, E.; Mesa, F.; Ikram, M.H.; Puertas, A.; Torrecillas-Martínez, L.; Ortega-Oller, I.; Magán-Fernández, A.; Rodríguez-Martínez, M.D.; Padial-Molina, M.; Sánchez-Fernández, E.; et al. Preterm birth and/or low birth weight are associated with periodontal disease and the increased placental immunohistochemical expression of inflammatory markers. Histol. Histopathol. 2016, 31, 231–237, Erratum in Histol Histopathol.2020, 35, 1211. [Google Scholar] [CrossRef] [PubMed]
- Ren, H.; Du, M. Role of Maternal Periodontitis in Preterm Birth. Front. Immunol. 2017, 8, 139. [Google Scholar] [CrossRef]
- Usin, M.M.; Menso, J.; Rodríguez, V.I.; Gonzalez, A.; Tabares, S.; Parodi, R.; Sembaj, A. Association between maternal periodontitis and preterm and/or low birth weight infants in normal pregnancies. J. Matern. Fetal Neonatal. Med. 2016, 29, 115–119. [Google Scholar] [CrossRef]
- Uwambaye, P.; Munyanshongore, C.; Rulisa, S.; Shiau, H.; Nuhu, A.; Kerr, M.S. Assessing the association between periodontitis and premature birth: A case control study. BMC Pregnancy Childbirth 2021, 21, 204. [Google Scholar] [CrossRef]
- Minić, I.; Pejčić, A. Parodontopathy as a Risk Factor for Premature Birth. Dentist 2019, 1, 1001. [Google Scholar]
- Papapanou, P.N.; Sanz, M.; Buduneli, N.; Dietrich, T.; Feres, M.; Fine, D.H.; Flemmig, T.F.; Garcia, R.; Giannobile, W.V.; Graziani, F.; et al. Periodontitis: Consensus report of workgroup 2 of the 2017 World Workshop on the Classification of Periodontal and Peri-Implant Diseases and Conditions. J. Periodontol. 2018, 89 (Suppl. S1), S173–S182. [Google Scholar] [CrossRef]
- Starzynska, A.; Wychowanski, P.; Nowak, M.; Sobocki, B.K.; Jereczek-Fossa, B.A.; Słupecka-Ziemilska, M. Association between Maternal Periodontitis and Development of Systematic Diseases in Offspring. Int. J. Mol. Sci. 2022, 23, 2473. [Google Scholar] [CrossRef]
- Offenbacher, S.; Beck, J.D.; Lieff, S.; Slade, G. Role of periodontitis in systemic health: Spontaneous preterm birth. J Dent. Educ. 1998, 62, 852–858. [Google Scholar] [CrossRef]
- Williams, R.C.; Offenbacher, S. Periodontal medicine: The emergence of a new branch of periodontology. Periodontol 2000 2000, 23, 9–12. [Google Scholar] [CrossRef]
- Tellapragada, C.; Eshwara, V.K.; Bhat, P.; Acharya, S.; Kamath, A.; Bhat, S.; Rao, C.; Nayak, S.; Mukhopadhyay, C. Risk factors for preterm birth and low birth weight among pregnant Indian women: A hospital-based prospective study. J. Prev. Med. Public Health 2016, 49, 165–175. [Google Scholar] [CrossRef]
- Thakur, R.K.; Yadav, B.K.; Sultana, R.; Afridi, S.K.; Das, D.; Sahoo, S.K. Influence of Periodontal Infection as a Possible Risk Factor for Preterm Low Birth Weight. J. Pharm. Bioallied. Sci. 2020, 12 (Suppl. S1), S613–S618. [Google Scholar] [CrossRef]
- Ye, C.; Xia, Z.; Tang, J.; Khemwong, T.; Kapila, Y.; Kuraji, R.; Ping, H.; Wu, Y.; Kobayashi, H. Unculturable and culturable periodontal-related bacteria are associated with periodontal inflammation during pregnancy and with preterm low birth weight delivery. Sci. Rep. 2020, 10, 15807. [Google Scholar] [CrossRef]
- WHO. Global Nutrition Targets 2025: Low Birth Weight Policy Brief; World Health Organization: Geneva, Switzerland, 2014; Available online: https://www.who.int/publications/i/item/WHO-NMH-NHD-14.5 (accessed on 30 December 2014).
- Perin, J.; Mulick, A.; Yeung, D.; Villavicencio, F.; Lopez, G.; Strong, K.L.; Prieto-Merino, D.; Cousens, S.; Black, P.R.E.; Liu, L. Global, regional, and national causes of under-5 mortality in 2000-19: An updated systematic analysis with implications for the Sustainable Development Goals. Lancet Child Adolesc. Health 2022, 6, 106–115. [Google Scholar] [CrossRef]
- Yankov, Y.G.; Bocheva, Y. Comparative Characterization of Procalcitonin (Sensitivity, Specificity, Predictability, and Cut-Off Reference Values) as a Marker of Inflammation in Odontogenic Abscesses of the Head and Neck in the Female Population. Cureus 2023, 15, e48207. [Google Scholar] [CrossRef] [PubMed]
- Acharya, A.B.; Shetty, I.P.; Jain, S.; Padakannaya, I.; Acharya, S.; Shettar, L.; Thakur, S. Neutrophil-to-lymphocyte ratio and platelet-to-lymphocyte ratio in chronic periodontitis before and after nonsurgical therapy. J. Indian Soc. Periodontol. 2019, 23, 419–423. [Google Scholar] [CrossRef] [PubMed]
- Desvarieux, M.; Demmer, R.T.; Jacobs, D.R., Jr.; Rundek, T.; Boden-Albala, B.; Sacco, R.L.; Papapanou, P.N. Periodontal bacteria and hypertension: The oral infections and vascular disease epidemiology study (INVEST). J. Hypertens. 2010, 28, 1413–1421. [Google Scholar] [CrossRef] [PubMed]
- Zhao, L.Y.; Yang, D.D.; Ma, X.K.; Liu, M.M.; Wu, D.H.; Zhang, X.P.; Ruan, D.Y.; Lin, J.X.; Wen, J.Y.; Chen, J.; et al. The Prognostic Value of aspartate aminotransferase to lymphocyte ratio and systemic immune-inflammation index for Overall Survival of Hepatocellular Carcinoma Patients Treated with palliative Treatments. J. Cancer 2019, 10, 2299–2311. [Google Scholar] [CrossRef] [PubMed]
- Ishimine, N.; Honda, T.; Yoshizawa, A.; Kawasaki, K.; Sugano, M.; Kobayashi, Y.; Matsumoto, T. Combination of White Blood Cell Count and Left Shift Level Real-Timely Reflects a Course of Bacterial Infection. J. Clin. Lab. Anal. 2013, 27, 407–411. [Google Scholar] [CrossRef] [PubMed]
- Lee, J.S.; Kim, N.Y.; Na, S.H.; Youn, Y.H.; Shin, C.S. Reference values of neutrophil-lymphocyte ratio, lymphocyte-monocyte ratio, platelet-lymphocyte ratio, and mean platelet volume in healthy adults in South Korea. Medicine 2018, 97, e11138. [Google Scholar] [CrossRef] [PubMed]
- Hope, C.K.; Wang, Q.; Burnside, G.; Adeyemi, A.A.; Quenby, S.; Smith, P.W.; Higham, S.M.; Whitworth, M. Assessing the Association between Oral Hygiene and Preterm Birth by Quantitative Light-Induced Fluorescence. Sci. World J. 2014, 2014, 374694. [Google Scholar] [CrossRef] [PubMed]
- World Health Organization (WHO). Oral Health Survey. Basic Methods, 5th ed.; WHO Press: Geneva, Switzerland, 2013; pp. 1–125. [Google Scholar]
- Petersen, P.E.; Bourgeois, D.; Ogawa, H.; Estupinan-Day, S.; Ndiaye, C. The global burden of oral diseases and risks to oral health. Bull. World Health Organ. 2005, 83, 661–669. [Google Scholar]
- Solari, N.; Salas, L.; Tabares, S.; Rosella, C.; Usin, M.M.; Sembaj, A. Immunological and Bacteriological Monitoring of Periodontal Tissue in Pregnancy.-ODOVTOS-Int. J. Dental Sc. 2023, 25, 133–143. [Google Scholar]
- Amparo, G.L.; De Avila, J.; Castillo, D.M.; Montenegro, D.A.; Trujillo, T.G.; Suárez, L.J.; Lafaurie, G.I. Porphyromonas gingivalis Placental Atopobiosis and Inflammatory Responses in Women with Adverse Pregnancy Outcomes. Front. Microbiol. 2020, 11, 591626. [Google Scholar] [CrossRef]
- Könönen, E.; Dareen, F.; Gursoy, U.K.; Gursoy, M. Prevotella species as oral residents and infectious agents with potential impact on systemic conditions. J. Oral Microbiol. 2022, 14, 2079814. [Google Scholar] [CrossRef]
- Suzuki, N.; Yoneda, M.; Hirofujj, T. Mixed red-complex bacterial infection in periodontitis. Int. J. Dent. 2013, 58, 72–79. [Google Scholar] [CrossRef]
- Vidmar Šimic, M.; Maver, A.; Zimani, A.N.; Hočevar, K.; Peterlin, B.; Kovanda, A.; Premru-Sršen, T. Oral microbiome and preterm birth. Front. Med. 2023, 10, 1177990. [Google Scholar] [CrossRef]
- Urushiyama, D.; Suda, W.; Ohnishi, E.; Araki, R.; Kiyoshima, C.; Kurakazu, M.; Sanui, A.; Yotsumoto, F.; Murata, M.; Nabeshima, K.; et al. Microbiome profile of the amniotic fluid as a predictive biomarker of perinatal outcome. Sci. Rep. 2017, 7, 12171. [Google Scholar] [CrossRef]
Pocket Lesion | Score 1 | Furcation Involvement | Score 2 |
---|---|---|---|
<5 pockets 5–6 mm | 1 | <3 furcations of class I | 1 |
≥5 pockets 5–6 mm | 2 | ≥3 or <3 furcations of class I or II | 2 |
<5 pockets 7–8 mm | 3 | >3 or <3 furcations of class II or III | 3 |
≥5 pockets 7–8 mm | 4 | ≥3 furcations of class III | 4 |
<3 pockets ≥9 mm | 5 | - | - |
≥3 pockets ≥9 mm | 6 | - | - |
PIRI scores | score 1 + score 2 |
Indicators | Preterm Birth | Full-Term Birth | t | p-Value |
---|---|---|---|---|
Decay | 5.43 ± 2.4 | 3.76 ± 1.82 | −3.78 | 0.001 |
Filling | 1.52 ± 1.25 | 1.55 ± 0.995 | 0.046 | 0.96 * |
Missing | 1.86 ± 1.14 | 1.67 ± 1.22 | −0.78 | 0.44 * |
DMF | 8.81 ± 3.88 | 6.95 ± 2.7 | −2.67 | 0.009 |
Caries severity level | 0.31 ± 0.11 | 0.25 ± 0.97 | −2.7 | 0.009 |
Indicators | Preterm Birth | Full-Term Birth | t | p-Value |
---|---|---|---|---|
CPI 0 | 0.31 ± 0.78 | 1.66 ± 1.69 | 5.3 | 0.001 |
CPI 1 | 0.88 ± 0.99 | 1.62 ± 1.4 | 3.1 | 0.003 |
CPI 2 | 2.26 ± 0.86 | 2.05 ± 1.4 | −0.9 | 0.36 * |
CPI 3 | 1.88 ± 1.06 | 0.34 ± 0.8 | −7.8 | 0.001 |
CPI 4 | 0.31 ± 0.6 | 0.03 ± 0.26 | −2.76 | 0.008 |
CPI excluded | 0.38 ± 0.5 | 0.28 ± 0.49 | −1.06 | 0.29 * |
Amniotic Fluid | Aggregatobacter spp. | Tannerella forsythia | Fusobacterium nucleatum | Prevotella intermedia | Porphyromonas gingivalis | Staph. aureus | Candida albicans | |
---|---|---|---|---|---|---|---|---|
Gingival Fluid | ||||||||
Aggregatobacter spp. | 0.498 (p = 0.001) | 0.369 (p = 0.016) | - | - | - | - | - | |
Fusobacterium nucleatum | 0.701 (p < 0.001) | - | - | - | - | - | - | |
Prevotella intermedia | - | - | 0.406 (p = 0.008) | 0.408 (p = 0.007) | 0.334 (p = 0.031) | 0.371 (p = 0.016) | - | |
Porphyromonas gingivalis | - | - | 0.372 (p = 0.015) | - | 0.32 (p = 0.039) | - | - | |
Staph. aureus | - | - | - | - | - | 0.826 (p = 0.001) | - | |
Candida albicans | - | - | - | - | - | 0.319 (p = 0.039) | 0.485 (p = 0.001) |
Microorganisms | Gingival Fluid | Amniotic Fluid | p-Value | r |
---|---|---|---|---|
Aggregatobacter spp. | 69% | 39.7% | <0.001 | 0.544 * |
T. forsythia | 63.8% | 32.8% | <0.001 | 0.526 * |
Fusobacterium nucleatum | 60.3% | 34.5 | <0.001 | 0.588 * |
P. intermedia | 55.2% | 24.1 | <0.001 | 0.508 * |
Porphyromonas gingivalis | 53.4% | 32.8 | <0.001 | 0.651 * |
Staph. aureus | 51.7% | 24.1 | <0.001 | 0.545 * |
Candida albicans | 43.1% | 29.3 | 0.01 | 0.663 * |
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Hakobyan, M.; Manrikyan, G.; Markaryan, M.; Vardanyan, I.; Manrikyan, M. The Influence of Dental Status and Blood Parameters Characterizing Endogenous Intoxication on the Timing of Childbirth. Medicina 2024, 60, 1176. https://doi.org/10.3390/medicina60071176
Hakobyan M, Manrikyan G, Markaryan M, Vardanyan I, Manrikyan M. The Influence of Dental Status and Blood Parameters Characterizing Endogenous Intoxication on the Timing of Childbirth. Medicina. 2024; 60(7):1176. https://doi.org/10.3390/medicina60071176
Chicago/Turabian StyleHakobyan, Maria, Gayane Manrikyan, Marina Markaryan, Izabella Vardanyan, and Mikayel Manrikyan. 2024. "The Influence of Dental Status and Blood Parameters Characterizing Endogenous Intoxication on the Timing of Childbirth" Medicina 60, no. 7: 1176. https://doi.org/10.3390/medicina60071176