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Marine Drugs
Volume 14
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10.3390/md14070123
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Article

Structural Features and Potent Antidepressant Effects of Total Sterols and β-sitosterol Extracted from Sargassum horneri

by
Donghai Zhao
1,*,†,
Lianwen Zheng
2,†,
Ling Qi
1,
Shuran Wang
1,
Liping Guan
3,
Yanan Xia
3 and
Jianhui Cai
1,*
1
The Basic Medical College, Jilin Medical University, Jilin 132013, China
2
The Second Hospital, Jilin University, Changchun 130041, China
3
Food and Pharmacy College, Zhejiang Ocean University, Zhoushan 316022, China
*
Authors to whom correspondence should be addressed.
†
These authors contributed equally to this work.
Mar. Drugs 2016, 14(7), 123; https://doi.org/10.3390/md14070123
Submission received: 6 May 2016 / Revised: 18 June 2016 / Accepted: 21 June 2016 / Published: 28 June 2016
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Abstract

The purified total sterols and β-sitosterol extracted from Sargassum horneri were evaluated for their antidepressant-like activity using the forced swim test (FST) and tail suspension test (TST) in mice. Total sterols and β-sitosterol significantly reduced the immobility time in the FST and TST. Total sterols were administered orally for 7 days at doses of 50, 100, and 200 mg/kg, and β-sitosterol was administered intraperitoneally at doses of 10, 20, and 30 mg/kg. β-sitosterol had no effect on locomotor activity in the open field test. In addition, total sterols and β-sitosterol significantly increased NE, 5-HT, and the metabolite 5-HIAA in the mouse brain, suggesting that the antidepressant-like activity may be mediated through these neurotransmitters.
Keywords: Sargassum horneri; sterols; β-sitosterol; FST; TST; monoamine neurotransmitters Sargassum horneri; sterols; β-sitosterol; FST; TST; monoamine neurotransmitters
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MDPI and ACS Style

Zhao, D.; Zheng, L.; Qi, L.; Wang, S.; Guan, L.; Xia, Y.; Cai, J. Structural Features and Potent Antidepressant Effects of Total Sterols and β-sitosterol Extracted from Sargassum horneri. Mar. Drugs 2016, 14, 123. https://doi.org/10.3390/md14070123

AMA Style

Zhao D, Zheng L, Qi L, Wang S, Guan L, Xia Y, Cai J. Structural Features and Potent Antidepressant Effects of Total Sterols and β-sitosterol Extracted from Sargassum horneri. Marine Drugs. 2016; 14(7):123. https://doi.org/10.3390/md14070123

Chicago/Turabian Style

Zhao, Donghai, Lianwen Zheng, Ling Qi, Shuran Wang, Liping Guan, Yanan Xia, and Jianhui Cai. 2016. "Structural Features and Potent Antidepressant Effects of Total Sterols and β-sitosterol Extracted from Sargassum horneri" Marine Drugs 14, no. 7: 123. https://doi.org/10.3390/md14070123

APA Style

Zhao, D., Zheng, L., Qi, L., Wang, S., Guan, L., Xia, Y., & Cai, J. (2016). Structural Features and Potent Antidepressant Effects of Total Sterols and β-sitosterol Extracted from Sargassum horneri. Marine Drugs, 14(7), 123. https://doi.org/10.3390/md14070123

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