4-(Phenylsulfanyl) Butan-2-One Attenuates the Inflammatory Response Induced by Amyloid-β Oligomers in Retinal Pigment Epithelium Cells
Abstract
:1. Introduction
2. Results
2.1. The Addition of oAβ1-42 Caused Morphological Changes and Mild Cell Death in ARPE-19 Cells
2.2. 4-PSB-2 Increased Cell Viability in ARPE-19 Cells
2.3. 4-PSB-2 Repressed Elevated Expression of Inflammation Markers in oAβ1-42-Treated ARPE-19 Cells
2.4. 4-PSB-2 Attenuates Inflammatory Responses through NF-κB Signaling in ARPE-19 Cells
3. Discussion
4. Materials and Methods
4.1. Cell Culture
4.2. Preparation of Oligomeric Aβ1-42 Solution
4.3. Preparation of 4-PSB-2 Solution and Treatment
4.4. Cell Viability Assay
4.5. Western Blot Analysis
4.6. Immunocytochemical Staining and Image Analysis
4.7. Statistical Analysis
5. Conclusions
Author Contributions
Funding
Acknowledgments
Conflicts of Interest
References
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Varinthra, P.; Huang, S.-P.; Chompoopong, S.; Wen, Z.-H.; Liu, I.Y. 4-(Phenylsulfanyl) Butan-2-One Attenuates the Inflammatory Response Induced by Amyloid-β Oligomers in Retinal Pigment Epithelium Cells. Mar. Drugs 2021, 19, 1. https://doi.org/10.3390/md19010001
Varinthra P, Huang S-P, Chompoopong S, Wen Z-H, Liu IY. 4-(Phenylsulfanyl) Butan-2-One Attenuates the Inflammatory Response Induced by Amyloid-β Oligomers in Retinal Pigment Epithelium Cells. Marine Drugs. 2021; 19(1):1. https://doi.org/10.3390/md19010001
Chicago/Turabian StyleVarinthra, Peeraporn, Shun-Ping Huang, Supin Chompoopong, Zhi-Hong Wen, and Ingrid Y. Liu. 2021. "4-(Phenylsulfanyl) Butan-2-One Attenuates the Inflammatory Response Induced by Amyloid-β Oligomers in Retinal Pigment Epithelium Cells" Marine Drugs 19, no. 1: 1. https://doi.org/10.3390/md19010001