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Mar. Drugs, Volume 2, Issue 4 (December 2004) – 5 articles , Pages 154-191

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164 KiB  
Article
Philinopgenin A, B, and C, Three New Triterpenoid Aglycones from the Sea Cucumber Pentacta quadrangulasis
by Shi-Long Zhang, Ling Li, Yang-Hua Yi, Zheng-Rong Zou and Peng Sun
Mar. Drugs 2004, 2(4), 185-191; https://doi.org/10.3390/md204185 - 25 Nov 2004
Cited by 14 | Viewed by 9699
Abstract
Three new triterpenoid aglycones named Philinopgenin A (1), B (2), and C (3) were isolated from the acid hydrolysate of the crude glycoside mixture prepared from the whole sea cucumber Pentacta quadrangulasis Lesson. The corresponding structures were determined as 16β-acetoxyholosta-8(9), 24(25)-diene-3β-ol (1), 20, [...] Read more.
Three new triterpenoid aglycones named Philinopgenin A (1), B (2), and C (3) were isolated from the acid hydrolysate of the crude glycoside mixture prepared from the whole sea cucumber Pentacta quadrangulasis Lesson. The corresponding structures were determined as 16β-acetoxyholosta-8(9), 24(25)-diene-3β-ol (1), 20, 25-epoxy-lanosta-9(11)-ene-3β-ol 18(16)–lactone (2) and 16β-acetoxyholosta-9(11), 24(25)-diene-3β-ol (3), respectively, on the basis of spectral evidence. Full article
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124 KiB  
Article
1-O-Sulfatobastadins-1 and -2 from Ianthella basta (Pallas).Antagonists of the yR1-FKBP12 Ca2+ Channel
by Makoto N. Masuno, Alexander C. Hoepker, Isaac N. Pessah and Tadeusz F. Molinski
Mar. Drugs 2004, 2(4), 176-184; https://doi.org/10.3390/md204176 - 25 Nov 2004
Cited by 14 | Viewed by 9524
Abstract
Two new sulfate monoesters of hemibastadins-1 and -2 were isolated from the marine sponge Ianthella basta (Pallas) from Guam. A third new compound was tentatively assigned the structure 34-O-sulfatobastadin-9. The 1-O-sulfatohemibastadins-1 and –2 were antagonists of the RyR1-FKBP12 Ca2+ channel under conditions where [...] Read more.
Two new sulfate monoesters of hemibastadins-1 and -2 were isolated from the marine sponge Ianthella basta (Pallas) from Guam. A third new compound was tentatively assigned the structure 34-O-sulfatobastadin-9. The 1-O-sulfatohemibastadins-1 and –2 were antagonists of the RyR1-FKBP12 Ca2+ channel under conditions where the known compound bastadin-5 exhibits potent agonism (EC50 2μM). Full article
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181 KiB  
Article
Parguerol and Isoparguerol Isolated from the Sea Hare, Aplysia kurodai, Induce Neurite Outgrowth in PC-12 Cells
by Sachiko Tsukamoto, Yuko Yamashita, Takushi Yoshida and Tomihisa Ohta
Mar. Drugs 2004, 2(4), 170-175; https://doi.org/10.3390/md204170 - 25 Nov 2004
Cited by 10 | Viewed by 7781
Abstract
The extract of the sea hare, Aplysia kurodai, showed neurotrophic activity toward rat pheochromocytoma (PC-12) cells. Bioassay-guided purification afforded two active compounds, which were subsequently identified to be parguerol and isoparguerol by spectroscopic analysis. It was found that both parguerol and isoparguerol [...] Read more.
The extract of the sea hare, Aplysia kurodai, showed neurotrophic activity toward rat pheochromocytoma (PC-12) cells. Bioassay-guided purification afforded two active compounds, which were subsequently identified to be parguerol and isoparguerol by spectroscopic analysis. It was found that both parguerol and isoparguerol induced neurite outgrowth in PC-12 cells at concentrations of 25 and 50 μM, respectively. Full article
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59 KiB  
Article
Sporiolides A and B, New Cytotoxic Twelve-Membered Macrolides from a Marine-Derived Fungus Cladosporium Species
by Hideyuki Shigemori, Yuu Kasai, Kazusei Komatsu, Masashi Tsuda, Yuzuru Mikami and Jun’ichi Kobayashi
Mar. Drugs 2004, 2(4), 164-169; https://doi.org/10.3390/md204164 - 25 Nov 2004
Cited by 62 | Viewed by 9402
Abstract
Two new cytotoxic twelve-membered macrolides, sporiolides A (1) and B (2), were isolated from the cultured broth of a fungus Cladosporium sp., which was separated from an Okinawan marine brown alga Actinotrichia fragilis, and the structures were elucidated by spectroscopic data. Sporiolides [...] Read more.
Two new cytotoxic twelve-membered macrolides, sporiolides A (1) and B (2), were isolated from the cultured broth of a fungus Cladosporium sp., which was separated from an Okinawan marine brown alga Actinotrichia fragilis, and the structures were elucidated by spectroscopic data. Sporiolides A (1) and B (2) exhibited cytotoxicity against murine lymphoma L1210 cells. Spoliolide A (1) showed antifungal activity against Cryptococcus neoformans and Neurospora crassa. Full article
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106 KiB  
Article
Isolation of Araguspongine M, a New Stereoisomer of an Araguspongine/Xestospongin alkaloid, and Dopamine from the Marine Sponge Neopetrosia exigua Collected in Palau
by Hongwei Liu, Yuri Mishima, Takeshi Fujiwara, Hiroshi Nagai, Akira Kitazawa, Yuji Mine, Hisayoshi Kobayashi, Xinsheng Yao, Junko Yamada, Taiko Oda and Michio Namikoshi
Mar. Drugs 2004, 2(4), 154-163; https://doi.org/10.3390/md204154 - 25 Nov 2004
Cited by 40 | Viewed by 14231
Abstract
A new stereoisomer of an araguspongine/xestospongin alkaloid, named araguspongine M (1), has been isolated together with 12 known compounds, araguspongines B (2) and D (3), dopamine, three galactosyl diacylglycerols, 24-methyl cholesterol, 5,6-dihydrocholesterol, β-sitosterol, and three 5α,8α-epidioxy sterols (11–13), from the marine sponge Neopetrosia [...] Read more.
A new stereoisomer of an araguspongine/xestospongin alkaloid, named araguspongine M (1), has been isolated together with 12 known compounds, araguspongines B (2) and D (3), dopamine, three galactosyl diacylglycerols, 24-methyl cholesterol, 5,6-dihydrocholesterol, β-sitosterol, and three 5α,8α-epidioxy sterols (11–13), from the marine sponge Neopetrosia exigua (formerly Xestospongia exigua) collected in Palau. The structure of 1 was assigned on the basis of its spectral data analysis. This is the first report on the isolation of dopamine from a marine sponge. This compound may be produced by an endosymbiotic Synechococcus-like cyanobacterium. Compounds 1–3 and 11–13 showed cytotoxicity against HL-60 at IC50’s of 5.5, 5.5, 5.9, 22.4, 9.5, and 9.6 μM, respectively. The possible biosynthesis origin of the isolated metabolites is discussed. Full article
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