Fish Collagen Peptides Protect against Cisplatin-Induced Cytotoxicity and Oxidative Injury by Inhibiting MAPK Signaling Pathways in Mouse Thymic Epithelial Cells
, Hye-Yoon Kim 2,3,†, Ye Seon Lim 2,3, Seon Yeong Hwang 2,3, Changyong Lee 2,3, Do Young Lee 2,3, Yuseok Moon 2,4, Yong Jung Song 2,5 and Sik Yoon 2,3,*Round 1
Reviewer 1 Report
It is pleasant reading this article. The authors design a well-constructed hypothesis about Fish Collagen Peptides Protect Against Cisplatin-Induced Cytotoxicity and Oxidative Injury. Besides, I have some concerns and suggestions about the manuscripts.
Title: 1. Words like “Inhibiting p38 MAPK, JNK, and ERK” in the title should modify its looks like a conclusion.
- p38 and its phosphor form in figure 8 are not informative, replaced with another replicate.
- b-Actin blots are the same in fig A and B, western blot control in figure 4. And the same thing is in figure 10. Why this?
Author Response
We attached the file for a point-by-point response to the reviewer’s comments.
Author Response File: 
Author Response.docx
Reviewer 2 Report
Dear Editor,
The manuscript is well written and experiments are well performed. In my opinion, it is interesting, and I recommend its publication in the Journal after the following points:
-Why did the authors use SB203580, SP600125, U0126, and NAC for treatments?
-Add references for the material and method section.
-How did the authors select the protective dose of FCP and NAC, …?
-Provide the graphical abstract.
-How did the authors quantify the western results in fig 10? Explain in the method section.
-The discussion part can be improved by providing a more critical discussion of recent related literature.
Author Response
We attached the file for a point-by-point response to the reviewer’s comments.
Author Response File: 
Author Response.pdf
Round 2
Reviewer 2 Report
The authors have responded adequately to my previous comments. I have no more comments.
