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Marine Drugs, Volume 20, Issue 4

April 2022 - 54 articles

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Cover Story: Cryptosporidium sp. are apicomplexan parasites that cause diarrheal disease in humans and livestock worldwide. A Cryptosporidium growth inhibition assay was used to screen the HBOI fraction library. Bioassay-guided fractionation of active fractions from a deep-sea sponge, Leiodermatium sp., resulted in the purification of leiodolide A as the major active compound in the organism. Leiodolide A displayed specific anti-Cryptosporidium activity at an EC50 of 103.5 nM with good selectivity over host cells and other mammalian cell lines. Leiodolide A provides a valuable drug scaffold on which to develop new anti-Cryptosporidium compounds and encourages screening natural products for new chemical scaffolds. View this paper

Articles (54)

  • Article
  • Open Access
11 Citations
3,016 Views
15 Pages

18 April 2022

Chemical investigation of the Hainan soft coral Sinularia hirta resulted in the isolation and identification of a library of sixteen structurally diverse terpenoids, including a dinorditerpenoid with an uncommon 17,19-dinorxeniaphyllane skeleton, nam...

  • Review
  • Open Access
36 Citations
6,745 Views
24 Pages

18 April 2022

Phytoplankton are prominent organisms that contain numerous bioactive substances and secondary metabolites, including toxins, which can be valuable to pharmaceutical, nutraceutical, and biotechnological industries. Studies on toxins produced by phyto...

  • Article
  • Open Access
3 Citations
3,221 Views
14 Pages

Development of a High-Performance Thin-Layer Chromatography Method for the Quantification of Alkyl Glycerolipids and Alkenyl Glycerolipids from Shark and Chimera Oils and Tissues

  • Marion Papin,
  • Cyrille Guimaraes,
  • Benoit Pierre-Aue,
  • Delphine Fontaine,
  • Jeoffrey Pardessus,
  • Hélène Couthon,
  • Gaëlle Fromont,
  • Karine Mahéo,
  • Aurélie Chantôme and
  • Christophe Vandier
  • + 1 author

18 April 2022

Ether lipids are composed of alkyl lipids with an ether bond at the sn-1 position of a glycerol backbone and alkenyl lipids, which possess a vinyl ether bond at the sn-1 position of the glycerol. These ether glycerolipids are present either as polar...

  • Article
  • Open Access
8 Citations
4,891 Views
15 Pages

Discovery of New Secondary Metabolites from Marine Bacteria Hahella Based on an Omics Strategy

  • Shufen He,
  • Peishan Li,
  • Jingxuan Wang,
  • Yanzhu Zhang,
  • Hongmei Lu,
  • Liufei Shi,
  • Tao Huang,
  • Weiyan Zhang,
  • Lijian Ding and
  • Shan He
  • + 1 author

18 April 2022

Hahella is one characteristic genus under the Hahellaceae family and shows a good potential for synthesizing new natural products. In this study, we examined the distribution of the secondary metabolite biosynthetic gene cluster (SMBGC) under Hahella...

  • Article
  • Open Access
10 Citations
3,135 Views
11 Pages

A Survey on the Distribution of Ovothiol and ovoA Gene Expression in Different Tissues and Cells: A Comparative Analysis in Sea Urchins and Mussels

  • Carola Murano,
  • Annalisa Zuccarotto,
  • Serena Leone,
  • Marco Sollitto,
  • Marco Gerdol,
  • Immacolata Castellano and
  • Anna Palumbo

15 April 2022

Ovothiols are histidine-derived thiols produced by a variety of marine invertebrates, protists and bacteria. These compounds, which are among the strongest natural antioxidants, are involved in controlling the cellular redox balance due to their redo...

  • Article
  • Open Access
12 Citations
3,311 Views
16 Pages

Astaxanthin Confers a Significant Attenuation of Hippocampal Neuronal Loss Induced by Severe Ischemia-Reperfusion Injury in Gerbils by Reducing Oxidative Stress

  • Joon Ha Park,
  • Tae-Kyeong Lee,
  • Dae Won Kim,
  • Ji Hyeon Ahn,
  • Choong-Hyun Lee,
  • Jong-Dai Kim,
  • Myoung Cheol Shin,
  • Jun Hwi Cho,
  • Jae-Chul Lee and
  • Moo-Ho Won
  • + 1 author

14 April 2022

Astaxanthin is a powerful biological antioxidant and is naturally generated in a great variety of living organisms. Some studies have demonstrated the neuroprotective effects of ATX against ischemic brain injury in experimental animals. However, it i...

  • Review
  • Open Access
28 Citations
7,429 Views
14 Pages

14 April 2022

The world’s population growth and consequent increased demand for food, energy and materials together with the decrease of some natural resources have highlighted the compelling need to use sustainably existing resources and find alternative so...

  • Article
  • Open Access
3 Citations
3,095 Views
30 Pages

Cytotoxic Alkylynols of the Sponge Cribrochalina vasculum: Structure, Synthetic Analogs and SAR Studies

  • Dimitry Kovalerchik,
  • Ana Zovko,
  • Petra Hååg,
  • Adam Sierakowiak,
  • Kristina Viktorsson,
  • Rolf Lewensohn,
  • Micha Ilan and
  • Shmuel Carmeli

13 April 2022

A series of twenty-three linear and branched chain mono acetylene lipids were isolated from the Caribbean Sea sponge Cribrochalina vasculum. Seventeen of the compounds, 1–17, are new, while six, 18–23, were previously characterized from t...

  • Article
  • Open Access
2 Citations
3,630 Views
15 Pages

Evaluation of the Potential of Lipid-Extracted Chlorella vulgaris Residue for Yarrowia lipolytica Growth at Different pH Levels

  • Guillaume Delfau-Bonnet,
  • Nabila Imatoukene,
  • Tiphaine Clément,
  • Michel Lopez,
  • Florent Allais and
  • Anne-Lise Hantson

13 April 2022

Projections show that the cultivation of microalgae will extend to the production of bio-based compounds, such as biofuels, cosmetics, and medicines. This will generate co-products or residues that will need to be valorized to reduce the environmenta...

  • Article
  • Open Access
39 Citations
4,451 Views
16 Pages

Effect of Extraction Temperature on Pressurized Liquid Extraction of Bioactive Compounds from Fucus vesiculosus

  • Adane Tilahun Getachew,
  • Susan Løvstad Holdt,
  • Anne Strunge Meyer and
  • Charlotte Jacobsen

12 April 2022

This study was aimed at investigating the effect of low polarity water (LPW) on the extraction of bioactive compounds from Fucus vesiculosus and to examine the influence of temperature on the extraction yield, total phenolic content, crude alginate,...

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