Sulfated Glucan from the Green Seaweed Caulerpa sertularioides Inhibits Adipogenesis through Suppression of Adipogenic and Lipogenic Key Factors
and Susana Margarida Gomes Moreira 1,2,*
Round 1
Reviewer 1 Report
I recommend you to check the UCP-1, transcription factor related to the thermogenesis and lipogenesis. If it is possible, you can conclude more clearly the anti-adipogenesis effect of sulfated glucan from Caulerpa sertularioides.
Author Response
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Author Response File: 
Author Response.pdf
Reviewer 2 Report
1. Please keep the official short name for polysaccharide – PS. In case this Article sulfated PS as SPS.
2. Abstract: remove details such as concentration values
3. Results: The more details about amount of crude extract which was used to separation is needed. Also the yield of each fraction enriches this section
4. Please use a shorter name of seaweed when the full name was used during first mention: Caulerpa sertularioides and then C. sertularioides.
5. What is consists of fraction F0.9 except sugar (59.1%) and sulfate (11.2%) – 29.7% is needed to explanation
6. ....F0.9 fraction was separated to 10 fractions....(there are fractions not subfractions)
7. Lines 116-119. Please explain these sentences....”CS01 did not have its monosaccharide....” It is really unclear.
8. Glucose – Glc (official short), Rhamnose – Rha – Mannose – Man -please use these shorts
9. Line 149- please remove from the text
10. Line 153. Keep the space between next line
11. Discussion should be rewritten – please remove all details presented in Results section.
12. Methods: it is a section 4 (check the numbering)
Author Response
Please see the attachment
Author Response File: Author Response.pdf
