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Unraveling the Omega-3 Puzzle: Navigating Challenges and Innovations for Bone Health and Healthy Aging
by
Zayana Ali
Zayana Ali
Mohammad Ahmed Al-Ghouti
Mohammad Ahmed Al-Ghouti
Mohammad A. Al-Ghouti obtained his PhD in
Environmental Chemistry from Queen’s University in UK. [...]
Mohammad A. Al-Ghouti obtained his PhD in
Environmental Chemistry from Queen’s University in Belfast, UK. He is currently
a Professor of Environmental Chemistry and the Head of the Department of Biological and Environmental Sciences at the College of Arts and Sciences, Qatar
University. He has been listed among the top 2% of the most influential
scientists in the world across all sciences, according to a study conducted at
Stanford University based on the (Scopus) database for the years 2019, 2020, 2021, 2022, and 2023.
The focuses of his research include the preparation and modification of the
surfaces of adsorbents; the treatment of produced water, polymers, and
membranes; adsorption mechanisms and the influence of chemical and physical
characteristics on the remediation behavior of various environmental
compartments; environmental chemistry; membrane coating and technology; polymer
and membrane modification; controlling CaSO4 scaling and biofouling on reverse
osmosis membranes; nanoparticles for water treatment; municipal and industrial
wastewater; chemometric environmental remediation; cleaner production;
extraction processes; natural adsorbent chemistry; nano-adsorbents; waste
treatment; waste minimization; and water and wastewater treatment and
adsorption.
,
Haissam Abou-Saleh
Haissam Abou-Saleh
Md Mizanur Rahman
Md Mizanur Rahman
Md Mizanur Rahman obtained his MSc in Clinical Investigation
from the University of Texas Health at [...]
Md Mizanur Rahman obtained his MSc in Clinical Investigation
from the University of Texas Health Science Center at San Antonio (UTHSCSA),
USA, and his PhD in Medical Sciences (Microbiology and Immunology) from the
Saga Medical School, Japan, with a Fulbright scholarship from the Japanese
Government. He served as an Assistant Professor at the Department of Medicine
of the UTHSCSA, as an Adjunct Faculty in the Department of Biology at Texas
A&M University, and as a Special Graduate Faculty Member at the University
of Texas at San Antonio (UTSA). He joined the Department of Biological and
Environmental Sciences in the College of Arts and Sciences at Qatar University
as an Assistant Professor and then was promoted to Associate Professor. His
research focuses on the physiology and pathology of bone and muscle during
aging. His research group investigates the impact and underlying mechanisms of
calorie restriction, physical exercise, and natural products on healthy aging
and life span. His group is also working on the effect of natural products in
preventing and treating breast and prostate cancers, and the development of
drug resistance and underlying mechanisms.
1
Biological Science Program, Department of Biological and Environmental Sciences, College of Arts and Sciences, Qatar University, Doha P.O. Box 2713, Qatar
2
Environmental Science Program, Department of Biological and Environmental Sciences, College of Arts and Sciences, Qatar University, Doha P.O. Box 2713, Qatar
3
Biomedical Sciences Department, College of Health Sciences, Qatar University, Doha P.O. Box 2713, Qatar
*
Author to whom correspondence should be addressed.
Mar. Drugs 2024, 22(10), 446; https://doi.org/10.3390/md22100446 (registering DOI)
Submission received: 27 August 2024
/
Revised: 25 September 2024
/
Accepted: 26 September 2024
/
Published: 28 September 2024
Abstract
Omega-3 polyunsaturated fatty acids (ω-3 PUFAs, n-3 PUFAs), including eicosapentaenoic acid (EPA), docosahexaenoic acid (DHA), and alpha-linolenic acid (ALA), are essential polyunsaturated fats primarily obtained from fatty fish and plant-based sources. Compelling evidence from preclinical and epidemiological studies consistently suggests beneficial effects of ω-3 PUFAs on bone health and healthy aging processes. However, clinical trials have yielded mixed results, with some failing to replicate these benefits seen in preclinical models. This contraindication is mainly due to challenges such as low bioavailability, potential adverse effects with higher doses, and susceptibility to oxidation of ω-3 fatty acids, hindering their clinical effectiveness. This review comprehensively discusses recent findings from a clinical perspective, along with preclinical and epidemiological studies, emphasizing the role of ω-3 PUFAs in promoting bone health and supporting healthy aging. Additionally, it explores strategies to improve ω-3 PUFA efficacy, including nanoparticle encapsulation and incorporation of specialized pro-resolving mediators (SPM) derived from DHA and EPA, to mitigate oxidation and enhance solubility, thereby improving therapeutic potential. By consolidating evidence from various studies, this review underscores current insights and future directions in leveraging ω-3 PUFAs for therapeutic applications.
Share and Cite
MDPI and ACS Style
Ali, Z.; Al-Ghouti, M.A.; Abou-Saleh, H.; Rahman, M.M.
Unraveling the Omega-3 Puzzle: Navigating Challenges and Innovations for Bone Health and Healthy Aging. Mar. Drugs 2024, 22, 446.
https://doi.org/10.3390/md22100446
AMA Style
Ali Z, Al-Ghouti MA, Abou-Saleh H, Rahman MM.
Unraveling the Omega-3 Puzzle: Navigating Challenges and Innovations for Bone Health and Healthy Aging. Marine Drugs. 2024; 22(10):446.
https://doi.org/10.3390/md22100446
Chicago/Turabian Style
Ali, Zayana, Mohammad Ahmed Al-Ghouti, Haissam Abou-Saleh, and Md Mizanur Rahman.
2024. "Unraveling the Omega-3 Puzzle: Navigating Challenges and Innovations for Bone Health and Healthy Aging" Marine Drugs 22, no. 10: 446.
https://doi.org/10.3390/md22100446
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