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Open AccessReview
A Review of Sponge-Derived Diterpenes: 2009−2022
by
Jinmei Xia
Jinmei Xia 1,*,†,
Xiangwei Chen
Xiangwei Chen 1,2,†,
Guangyu Li
Guangyu Li 1,
Peng Qiu
Peng Qiu 1,
Weiyi Wang
Weiyi Wang 1,* and
Zongze Shao
Zongze Shao 1,*
1
Key Laboratory of Marine Biogenetic Resources, Third Institute of Oceanography, Ministry of Natural Resources, Xiamen 361005, China
2
Department of Pharmacy, NO. 971 Hospital of the People’s Liberation Army Navy, Qingdao 266000, China
*
Authors to whom correspondence should be addressed.
†
These authors contributed equally to this work.
Mar. Drugs 2024, 22(10), 447; https://doi.org/10.3390/md22100447 (registering DOI)
Submission received: 5 September 2024
/
Revised: 16 September 2024
/
Accepted: 26 September 2024
/
Published: 28 September 2024
Abstract
Abstract: Sponges are a vital source of pharmaceutically active secondary metabolites, of which the main structural types are alkaloids and terpenoids. Many of these compounds exhibit biological activities. Focusing specifically on diterpenoids, this article reviews the structures and biological activities of 228 diterpenes isolated from more than 33 genera of sponges from 2009 to 2022. The Spongia sponges produce the most diterpenoid molecules among all genera, accounting for 27%. Of the 228 molecules, 110 exhibit cytotoxic, antibacterial, antifungal, antiparasitic, anti-inflammatory, and antifouling activities, among others. The most prevalent activity is cytotoxicity, present in 54 molecules, which represent 24% of the diterpenes reported. These structurally and biologically diverse diterpenoids highlight the vast, yet largely untapped, potential of marine sponges in the discovery of new bioactive molecules for medicinal use.
Share and Cite
MDPI and ACS Style
Xia, J.; Chen, X.; Li, G.; Qiu, P.; Wang, W.; Shao, Z.
A Review of Sponge-Derived Diterpenes: 2009−2022. Mar. Drugs 2024, 22, 447.
https://doi.org/10.3390/md22100447
AMA Style
Xia J, Chen X, Li G, Qiu P, Wang W, Shao Z.
A Review of Sponge-Derived Diterpenes: 2009−2022. Marine Drugs. 2024; 22(10):447.
https://doi.org/10.3390/md22100447
Chicago/Turabian Style
Xia, Jinmei, Xiangwei Chen, Guangyu Li, Peng Qiu, Weiyi Wang, and Zongze Shao.
2024. "A Review of Sponge-Derived Diterpenes: 2009−2022" Marine Drugs 22, no. 10: 447.
https://doi.org/10.3390/md22100447
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