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Marine Drugs
Volume 22
Issue 3
10.3390/md22030138
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Article

Maximizing Polysaccharides and Phycoerythrin in Porphyridium purpureum via the Addition of Exogenous Compounds: A Response-Surface-Methodology Approach

by
Sanjiong Yi
1,
Ai-Hua Zhang
1,*,
Jianke Huang
1,*,
Ting Yao
1,
Bo Feng
1,
Xinghu Zhou
2,
Yadong Hu
2,* and
Mingxuan Pan
2
1
Jiangsu Province Engineering Research Center for Marine Bio-Resources Sustainable Utilization, College of Oceanography, Hohai University, Nanjing 210098, China
2
Jiangsu Innovation Center of Marine Bioresource, Jiangsu Coast Development Investment Co., Ltd., Jiangsu Coast Development Group Co., Ltd., Nanjing 210019, China
*
Authors to whom correspondence should be addressed.
Mar. Drugs 2024, 22(3), 138; https://doi.org/10.3390/md22030138
Submission received: 28 February 2024 / Revised: 18 March 2024 / Accepted: 19 March 2024 / Published: 21 March 2024
(This article belongs to the Special Issue Algal Cultivation for Obtaining High-Value Products)
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Abstract

Phycoerythrin and polysaccharides have significant commercial value in medicine, cosmetics, and food industries due to their excellent bioactive functions. To maximize the production of biomass, phycoerythrin, and polysaccharides in Porphyridium purpureum, culture media were supplemented with calcium gluconate (CG), magnesium gluconate (MG) and polypeptides (BT), and their optimal amounts were determined using the response surface methodology (RSM) based on three single-factor experiments. The optimal concentrations of CG, MG, and BT were determined to be 4, 12, and 2 g L−1, respectively. The RSM-based models indicated that biomass and phycoerythrin production were significantly affected only by MG and BT, respectively. However, polysaccharide production was significantly affected by the interactions between CG and BT and those between MG and BT, with no significant effect from BT alone. Using the optimized culture conditions, the maximum biomass (5.97 g L−1), phycoerythrin (102.95 mg L−1), and polysaccharide (1.42 g L−1) concentrations met and even surpassed the model-predicted maximums. After optimization, biomass, phycoerythrin, and polysaccharides concentrations increased by 132.3%, 27.97%, and 136.67%, respectively, compared to the control. Overall, this study establishes a strong foundation for the highly efficient production of phycoerythrin and polysaccharides using P. purpureum.
Keywords: Porphyridium purpureum; polysaccharide; phycoerythrin; response surface methodology; polypeptides; gluconate Porphyridium purpureum; polysaccharide; phycoerythrin; response surface methodology; polypeptides; gluconate

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MDPI and ACS Style

Yi, S.; Zhang, A.-H.; Huang, J.; Yao, T.; Feng, B.; Zhou, X.; Hu, Y.; Pan, M. Maximizing Polysaccharides and Phycoerythrin in Porphyridium purpureum via the Addition of Exogenous Compounds: A Response-Surface-Methodology Approach. Mar. Drugs 2024, 22, 138. https://doi.org/10.3390/md22030138

AMA Style

Yi S, Zhang A-H, Huang J, Yao T, Feng B, Zhou X, Hu Y, Pan M. Maximizing Polysaccharides and Phycoerythrin in Porphyridium purpureum via the Addition of Exogenous Compounds: A Response-Surface-Methodology Approach. Marine Drugs. 2024; 22(3):138. https://doi.org/10.3390/md22030138

Chicago/Turabian Style

Yi, Sanjiong, Ai-Hua Zhang, Jianke Huang, Ting Yao, Bo Feng, Xinghu Zhou, Yadong Hu, and Mingxuan Pan. 2024. "Maximizing Polysaccharides and Phycoerythrin in Porphyridium purpureum via the Addition of Exogenous Compounds: A Response-Surface-Methodology Approach" Marine Drugs 22, no. 3: 138. https://doi.org/10.3390/md22030138

APA Style

Yi, S., Zhang, A.-H., Huang, J., Yao, T., Feng, B., Zhou, X., Hu, Y., & Pan, M. (2024). Maximizing Polysaccharides and Phycoerythrin in Porphyridium purpureum via the Addition of Exogenous Compounds: A Response-Surface-Methodology Approach. Marine Drugs, 22(3), 138. https://doi.org/10.3390/md22030138

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